Overweight and elevated BMI can increase the risk of breast cancer in postmenopausal women. On the other hand, it seems that exercise training affect weight and BMI. The aim of this study was to investigate the effects of exercise training on some anthropometric variables in postmenopausal women with breast cancer. Thus, 29 postmenopausal women with breast cancer who received surgery, chemotherapy and radiation-therapy were divided into two groups, intervention and control. Subjects of intervention group performed 15 weeks of exercise training including walking (2 sessions per week) and resistance training (2 sessions per week, different from walking days). Before and after 15 weeks, weight, BMI, WHR, Vo2max, blood pressure and rest heart rate were measured in two groups. Data were analyzed using ANOVA. Results indicated significant differences in weight, BMI, WHR, Vo2max and rest heart rate between intervention and control groups (p<0.05). In fact, exercise training had significant effects on the weight, BMI, WHR, Vo2max and rest heart rate in postmenopausal females with breast cancer. However, there was no significant difference in blood pressure between the two groups. Therefore, exercise training can improve maximal aerobic capacity, rest heart rate and some anthropometric variables in postmenopausal women with breast cancer.