The Response of Vascular Endothelial Growth Factor to Exhausted Submaximal Exercise and Its Relationship with VO2max



The aim of this study was to investigate the response of vascular endothelial growth factor (VEGF) to a bout of exhausted submaximal exercise and its correlation with VO2max in different bouts. Therefore, 12 active men (mean age: 24 years) were randomly selected and performed the submaximal exercise. Blood samples were collected before, immediately and two¬¬ hours after the exercise training. Data were analyzed using one-way ANOVA and Pearson correlation coefficient (a=0.05). Serum VEGF increased significantly immediately (p=0.000) and two hours after the exercise (p=0.000). In addition, there was no significant relationship between serum VEGF and VO2max before the exercise training (p=0.352) while there was a significant relationship immediately (p=0.006) and after two hours (p=0.026) after the exercise. In conclusion, one bout of exhausted submaximal exercise can be a stimulus to increase angiogenic factor of VEGF and the more the subjects’ aerobic power, the more they might experience angiogenesis.