The purpose of the present study was to compare some biochemical markers of cancer diseases risk between two groups of active and inactive postmenopausal women. For this purpose, 74 postmenopausal women were required to complete Baecke questionnaire. They were divided into two groups: active (age: 55.89±4.38 years, height: 156.93±0.05 cm, weight: 63.18±6.50 kg, body fat percentage: 26.25±6.29, body mass index: 25.79±2.37 kg/m2 ،VO2max: 34.02±5.08 ml/kg min) and inactive (age: 57±4.80 years, height: 156.95±0.052 cm, weight: 65.9±7.67 kg, body fat percentage: 27.07±6.44, body mass index: 26.69±1.95 kg/m2, VO2max 24.21±2.10 ml/kg/min). Blood samples were gathered in a fasting state. Independent T test was used to analyze data. The results of this study showed that IGF-1 level was significantly higher in active postmenopausal women than inactive postmenopausal women. There were not significant difference between active and inactive postmenopausal women in IGFBP-3, , insulin, glucose and insulin resistance index. In conclusion, chronic physical activity could cause optimal levels for biochemical markers of cancer diseases risk.