Obesity in known to increase the risk for cardiovascular diseases. Serum levels of cellular adhesion molecules are reported to be indices of arthrosclerosis. So each intervention that has benefit effects on them is very important foe general health. The purpose of this study was to determine the effect of low and high intensity endurance training programs on ICAM-, 27 sedentary obese males with MEAN?SD age, %BF, weight and BMI : Exp 1(20.55? 1.34 y, 26.84? 4.07, 93.05 ?9.02 kg and 30.55? 2.84 kg/m2) were randomly divided to three groups. The training programs consist for 4 months, three sessions of 45-60 min with an intensity of 40%-45 (Exp 1) and %80-85 (Exp2) at heart rate reserve. The Blood sampling was performed after 18 fasting hours in baseline and 48 h after final training sessions with the same conditions. Resulting data were analyzed by ANOVA and Bonforoni Post hoc of pre to post differences, person correlation coefficient and pair t-test (?=0.05) . Data analysis showed that ICAM-1 decreased in both experimental groups but only was significant in EXP 2(P=0.015). There was no relationship between baseline of sICAM-1 with physical variable and lipid profile (P>0.05). There was positive correlation between %BF and BFM changes and ICAM-1 changes (P<0.05). The TC, LDL- C and RF levels significantly decreased. HDL-C levels in high intensity training group significantly increased (P<0.05).