The aim of this research was to evaluate the effect of one session of exhaustive exercise with low intensity (55-65% VO2max), moderate intensity (65-75% VO2max) and high intensity (75-85% VO2max) on adiponectin in active women. For this purpose, 30 healthy women (mean age 21.6 years, weigh 59.7+3.35 kg, VO2max 39.1+0.58 ml/kg/min, no history of cardiovascular diseases and diabetes) were selected and divided into three groups: low intensity active (LAG), moderate intensity active (MAG) and high intensity active (HAG). The protocol was a progressive running up to exhaustion on a treadmill with 55-65%, 65-75% and 75-85% of VO2max intensity according to Karvonen formula. Blood samples were obtained before and 30 minutes after the training in the same condition and following 12-14 hours of fasting. 7 ml of blood was obtained from the subjects' forearm vein in a sitting position and transported to the laboratory. Adiponectin, glucose and insulin were measured by ELISA and TG and LDL-C by enzymatic methods. Data were analyzed by T-test and analysis variance at P?0.05. Results showed that adiponectin level increased in three groups (LAG, MAG, HAG) but this increase was significant only in LAG group (P=0.01). On the other hand, adiponectin did not significantly change among groups. Although T- test analysis showed that glucose decreased significantly in all groups and insulin concentration changed significantly in MAG and HAG, insulin changes were insignificant between MAG and HAG only. This research showed that an increase in the training intensity and a decrease in duration slightly changed serum adiponectin in active young women.