Plasma levels of adhesion molecule and lipid profile have emerged as an important indicator of risk for cardiovascular diseases. The aim of the study was to evaluate the effects of regular physical activity on cardiovascular markers (ICAM-1, VCAM-1) in sedentary obese men. Eighteen young sedentary obeses males (mean and SD of age, weight and BMI were respectively as follows: 20.1? 0.97 years, 93.3?10.70 kg and 30.7?3.4 cm/m2) were voluntary assigned and randomly divided into two groups: experimental (N=9) and Control (N=9)]. The training program includes 16 weeks of running aerobic activity, 3 sessions a week, each session 45-60 minutes at 60%-65% reserve heart rate. Fasting blood sample were analyzed for ICAM-1, VCAM-1 levels and lipid profile before and at the end of the study. Data analysis with pair t test showed that ICAM-1 level decrease in the experimental groups (P=0.01, 7%) and VCAM-1 decreased as well (P>0.05, 10%). The levels of TC (P=0.04, 19%) LDL-C (P=0.04, 30%) and risk factors decrease significantly. HDL-C increase in the experimental group (7.5%, P>0.05). The WHR (P<0.05, 2.1%), weight and BMI in experimental group significantly decrease (P<0.05). A moderate relationship was observed in WHR with ICAM-1 (R=0.40) and VCAM-1(R=0.32). Also the moderate correlation was observed between changes of BF% and LDL-C with ICAM-1 (R=0.47, P>0.05). The results showed that changes in cholesterol, LDL-C and VCAM-1 will be possible if exercise is performed with 60%-65% reserved heart rate. On the other hand, although changes of BF%, weight and central obesity in subjects happened parallel with a decrease in VCAM-1 levels , there is not significant correlation among them in young men.