The present study examined the effect of endurance training on lipid profile, body weight and cardiovascular endurance in normal male rats after bunium persicum extract administration. 40 experimental male rats were divided into 5 groups: control, placebo, endurance training (ET), bunium persicum extract administer (BPEA) and ET – BPEA group. The exercise protocol was performed at a speed of 25 m/min., 90 min./day, 5 days/week for 6 weeks. The bunium persicum extract was administered for the same period and the desired dose (5 mg) was reconstituted in 1.5 ml of distilled water. At the beginning and the end of this period, changes in triglyceride, total cholesterol, HDL-C, LDL-C, body weight and cardiovascular endurance were compared. Data were analyzed with one-way ANAOVA. The results indicated that the 6-week endurance training accompanied by bunium persicum extract administration increased HDL-C significantly and reduced TG, TC and LDL-C concentrations but these changes were not significant (P=0.013). Meanwhile, results showed that body weight changes were not significant (P=0.26) but cardiovascular endurance significantly increased (P=0.001). These results suggested that this protocol affected HDL-C concentration, cardiovascular endurance and body weight protection. Therefore, such protocols may be useful to prevent cardiovascular diseases.