Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
1 Department of exercise physiology and corrective movements, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
2 professor of exercise physiology, Urumia University, urumia, Iran
3 Department of Basic Sciences, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract
Background and Purpose: Type 2 diabetes is associated with hyperglycemia, insulin resistance, and oxidative stress. This study evaluated the separate and combined effects of high-intensity interval training (HIIT) and Burdock extract on metabolic and oxidative–antioxidant indices in a diabetic animal model.
Methods: Fifty male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + Burdock, diabetic + HIIT, and diabetic + HIIT + Burdock. Blood glucose, insulin, insulin resistance (HOMA-IR), insulin sensitivity (QUICKI), MDA, GPx, and TAC were measured. Analysis was performed using one-way ANOVA followed by post hoc tests (Tukey/Welch), with a significance level set at p<0.05.
Results: Compared to the diabetic group, each of the interventions (HIIT and Burdock alone) significantly reduced glucose and HOMA-IR, and increased insulin and TAC (p<0.05), while also significantly reducing MDA. The increase in GPx was significant in the Burdock and combined groups but not in the HIIT-only group (p<0.05). Only the combined HIIT + Burdock intervention significantly improved QUICKI (p<0.01), and it showed the greatest reduction in glucose and MDA, as well as the highest increase in insulin, GPx, and TAC (p≤0.001).
Conclusions: Both HIIT and Burdock have beneficial effects on glucose control and the oxidative/antioxidant balance. However, their combined use shows an additive effect, outperforming the individual interventions. These findings support the development of multi-faceted approaches in managing type 2 diabetes.
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