The Effect of Olive Leaf Extract Supplementation and High-Intensity Circuit Training on Serum Salusin Alpha and Beta Levels and Insulin Resistance in Obese Elderly Women

Bahram, Zahra; Pourvaghar, Mohammad Javad; Bahram, Mohammad Ebrahim

doi:10.22059/jsb.2025.399677.1682

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

Department of Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.

10.22059/jsb.2025.399677.1682

Abstract

Introduction: Systemic inflammation is a common symptom of obesity-related aging, with levels of atherosclerotic cytokines increasing two- to fourfold. The present study aimed to investigate the effect of eight weeks of high-intensity circuit training (HICT) and olive leaf extract supplementation on serum Salusin alpha and beta levels and insulin resistance in obese elderly women.
Methods: In this quasi-experimental study, 40 obese elderly women were randomly assigned to four equal groups: Placebo, Supplement, Exercise, and Supplement + Exercise. The HICT protocol was performed three times per week for eight weeks, with each session lasting 45 to 60 minutes. The Participants in the supplement groups consumed one 125 mg capsule of olive leaf extract daily after lunch for eight weeks. Blood samples were collected from all four groups before and after the test. Data were analyzed using one-way ANOVA, Tukey’s post hoc test, and paired t-test at a significance level of P < 0.05.
Results: The results of one-way ANOVA revealed a significant increase in salusin alpha (P=0.001, F=18.66) and significant decreases in salusin beta (P=0.001, F=11.73) and insulin resistance (P=0.001, F=23.30) across the groups. The results of the paired t-test indicated that in both the exercise and exercise + supplement groups, salusin beta and insulin resistance significantly decreased, while salusin alpha significantly increased.
Conclusion: It seems that prescribing HICT exercises along with olive leaf extract consumption exerts the greatest beneficial effect on improving atherosclerosis markers and insulin resistance in obese elderly women.

Keywords

Main Subjects

Exercise Physiology

References

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