Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
1 PhD student in exercise physiology, Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
2 Sport physiology department, Shiraz branch, Islamic Azad University, Shiraz, Iran
3 Associate professor in exercise physiology, Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
4 Associate professor in physiology, Department of biology, Shiraz branch, Islamic Azad University, Shiraz, Iran
Abstract
Introduction: Parkinson’s disease leads to mitochondrial damage caused by the production of Reactive Oxygen Species. The effect of sport activities on the improvement of Parkinson’s disease due to changes in the level of mitochondrial Cyt c and ATP of hippocampal cells is not well known, therefore, the present study aims to investigate the effect of high-intensity interval training on Cyt c and ATP in hippocampal cells of rats with Parkinson’s disease.
Methods: 21 male Wistar rats were divided into three groups, including: healthy control, PD and training. The rats in the training group performed 6 weeks HIIT, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time. Data were analyzed using one-way ANOVA and LSD post hoc test were run using SPSS-19 at the P <0.05.
Results: Data revealed that the induction of Parkinson increased the level of Cyt c in PD group compared to the healthy control group(P=0/001). The results showed that there is a significant difference between the groups in the concentration of Cyt c (P= 0/001). Also we observed that ATP in the exercise group and PD group decreased significantly compared to the control group, and it’s amount increased significantly in the exercise group compared to the PD group(P=0/001).
Conclusion: According to the results, it can be said, HIIT swimming training is effective in improving mitochondrial function. So, this type of exercise is recommended for people with PD
Keywords
Main Subjects
)