Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

1 . Department of Physical Education and Sports Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

2 , Department of Sports Sciences, Khomeinishahr Branch, Islamic Azad University, Isfahan, Iran.

3 Department of Physical Education and Sports Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

10.22059/jsb.2025.382795.1655

Abstract

Introduction: Obesity leads to negative changes in lipid profiles and genes related to reverse cholesterol transport. Exercise helps improve these changes. The aim of this study was the effect of eight of rhythmic aerobic and CX-WORX exercises on the expression of ABCG5/8 genes and lipid profile in obese women.

Method: The statistical population of this research was obese women with an age range of 20 to 30 years, of which 36 people were randomly divided into three rhythmic aerobic exercises(n=12), CX-WORX exercise (n=12) and control (n=12). Rhythmic aerobic exercise for eight weeks, four sessions each week and each session lasted approximately 60 to 95 minutes, The CX-WORX training program protocol was performed for 8 weeks with a frequency of three sessions per week and for 45 minutes per day. To investigate the difference between the groups, the statistical method of one-way analysis of variance and Tukey's post hoc test was used at a significance level of 0.05.

Findings: The study's findings showed that eight weeks of aerobic and CX-WORX exercises significantly increased the expression of ABCG5, ABCG8 genes, and HDL levels(P=0.001). In addition, the results showed a significant decrease in LDL, triglyceride, and cholesterol levels following the implementation of both training programs(P=0.001).

Conclusion: Based on these results, it can be stated that both exercise training models cause positive changes in the lipid profile and genes involved in reverse cholesterol transport, therefore, the use of these exercises is recommended to create positive physiological adaptations in increasing the health of obese women.

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