Sport Biosciences

The Effect of a Course of Swimming and Minocycline Exercises After Childhood Infection on Anxiety and Malondialdehyde Levels in the Hippocampus and Peripheral Cortex of NMRI Mice

Document Type : Research Paper

Authors

Rogayyeh Mahdavi 1
Saeid Naghibi 2
Ali Barzegari 1

1 Department of Exercise Physiology, Payame Noor University, Tehran, Iran.

2 Corresponding Author, Department of Exercise Physiology, Payame Noor University, Tehran, Iran.

https://doi.org/10.22059/jsb.2023.352436.1562
Abstract
Introduction: Infection in infancy increases the level of anxiety. The aim of this study was to evaluate the effect of a course of swimming exercises and minocycline medication after childhood infection on the level of anxiety and malondialdehyde levels in the hippocampus and peripheral cortex of NMRI mice.

Methods: In order to induce infection, on the third and fifth day after birth, the animals received lipopolysaccharide for 15 days. Animals were divided into 5 groups, consist of control, LPS; LPS+ Min; LPS + Ex and LPS+ Ex +Min were divided. The duration of the course was 4 weeks and the dose of minocycline was 20 mg/kg. The Open Field test anxiety was used to measure anxiety levels. One-way ANOVA with Tukey's post hoc test at a significance level of 0.05 was used.

Results: MDA levels in the LPS group were the highest in both the hippocampus and prefrontal sections compared to the Control group (P ≥ 0.05). The percentage of hippocampal MDA changes in the LPS+Min+EX group decreased by 14% compared to the control group, and the prefrontal MDA of the LPS+Min+EX group increased by 20% compared to the control group. So that the elapsed time and the number of entries in the Open Field test were increased in the LPS+Min+Ex group compared to other groups and decreased in the LPS group (P ≤ 0.05).

Conclusion: The results showed that swimming exercise and minocycline can change the effects of anxiety caused by childhood infection with changes in MDA.

Keywords

Anxiety
Childhood Infection
Malondialdehyde
Minocycline
Swimming Exercises
Subjects
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  • Receive Date 14 December 2022
  • Revise Date 13 February 2023
  • Accept Date 14 February 2023

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