Sport Biosciences

Association of Different HIF1-α and VEGF Gene Genotypes with Changes in Aerobic Capacity Following Moderate-Intensity Endurance Training in Inactive Women -A Pilot Study

Document Type : Research Paper

Authors

Parviz Shojaei 1
Mehran Ghahramani 2
Sirous Farsi 3

1 Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran.

2 Corresponding Author, Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran

3 Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.

https://doi.org/10.22059/jsb.2022.336857.1504
Abstract
Introduction: This research aimed to investigate the relationship between HIF1-α and VEGF gene genotypes and changes in aerobic capacity following eight weeks of moderate-intensity endurance training in inactive women.
Methods: Twenty-three inactive women aged 34 to 43 years old were conveniently selected and performed aerobic training for eight weeks and five 30-minute sessions per week with an intensity of 55% to 75% of maximum heart rate. Before and after the training period, aerobic capacity was measured by the Bruce test. A saliva sample was taken and different genotypes of the HIF1-α gene including CC and different genotypes of the VEGF gene including GG, CG, and CC were measured. Statistical methods of Paired t-test and ANOVA were used to observe mean differences in aerobic capacity and the Restriction Fragment Length Polymorphism (RLFP) method was used to check genotypes.
Results: The results of changes in the aerobic capacity of the subjects and investigation of the relationship between the different genotypes of VEGF and HIF1-α genes following eight weeks of moderate-intensity endurance training, the aerobic capacity of CC and CT genotypes of the HIF1-α gene were equal pre and post-intervention (p=0.529). Also, GG, CC, and CG genotypes of the VEGF gene were equal to the CG genotype (p=0·873). The CT genotype of the HIF1-α gene has the most increase, but this increase was not significant.
 Conclusion: Therefore, Eight weeks of moderate-intensity endurance training increases the aerobic capacity of HIF1-a and VEGF gene profiles in inactive obese women, but the changes in aerobic capacity of these gene profiles are not significant.

Keywords

Aerobic power
Angiogenesis
Genotype
HIF1-α
VEGF
Subjects
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Sport Biosciences
Volume 14, Issue 2
Summer 2022
Pages 61-73

  • Receive Date 04 January 2022
  • Revise Date 23 May 2021
  • Accept Date 23 May 2021

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