TY - JOUR ID - 86363 TI - Association of Different HIF1-α and VEGF Gene Genotypes with Changes in Aerobic Capacity Following Moderate-Intensity Endurance Training in Inactive Women -A Pilot Study JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - Shojaei, Parviz AU - Ghahramani, Mehran AU - Farsi, Sirous AD - Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran. AD - Corresponding Author, Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran AD - Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran. Y1 - 2022 PY - 2022 VL - 14 IS - 2 SP - 61 EP - 73 KW - aerobic power KW - angiogenesis KW - genotype KW - HIF1-α KW - VEGF DO - 10.22059/jsb.2022.336857.1504 N2 - Introduction: This research aimed to investigate the relationship between HIF1-α and VEGF gene genotypes and changes in aerobic capacity following eight weeks of moderate-intensity endurance training in inactive women.Methods: Twenty-three inactive women aged 34 to 43 years old were conveniently selected and performed aerobic training for eight weeks and five 30-minute sessions per week with an intensity of 55% to 75% of maximum heart rate. Before and after the training period, aerobic capacity was measured by the Bruce test. A saliva sample was taken and different genotypes of the HIF1-α gene including CC and different genotypes of the VEGF gene including GG, CG, and CC were measured. Statistical methods of Paired t-test and ANOVA were used to observe mean differences in aerobic capacity and the Restriction Fragment Length Polymorphism (RLFP) method was used to check genotypes.Results: The results of changes in the aerobic capacity of the subjects and investigation of the relationship between the different genotypes of VEGF and HIF1-α genes following eight weeks of moderate-intensity endurance training, the aerobic capacity of CC and CT genotypes of the HIF1-α gene were equal pre and post-intervention (p=0.529). Also, GG, CC, and CG genotypes of the VEGF gene were equal to the CG genotype (p=0·873). The CT genotype of the HIF1-α gene has the most increase, but this increase was not significant. Conclusion: Therefore, Eight weeks of moderate-intensity endurance training increases the aerobic capacity of HIF1-a and VEGF gene profiles in inactive obese women, but the changes in aerobic capacity of these gene profiles are not significant. UR - https://jsb.ut.ac.ir/article_86363.html L1 - https://jsb.ut.ac.ir/article_86363_c27c072a0bff86d11f203057fd6aed20.pdf ER -