Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Doctoral student of Sports Physiology, Tabriz Azad University

2 President of Tehran Cycling Federation. Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran

3 Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran

4 Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran

5 Associate Professor in Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran



Introduction: The purpose of this study was to investigate the effect of running on a Complex wheel running on hippocampal histology and memory function in Alzhei-mer's disease model rats.


24 rats were randomly divided into three groups: control (C), Alzheimer's control (AC), and Alzheimer's + complex wheel training (AT). To induce Alzheimer’s disease in the Alzheimer's groups, combination of ketamine (60) and xylazine 8 mg/kg was infused into the hippocampus of rats. The group (AT) ran for 12 weeks on a complex rotating wheel, while the control groups (C and AC) were kept in cages for 12 weeks and did not participate in any training. In this research, the Tmaz test was used to test the spatial memory of mice. In order to analyze the data, one-way analysis of variance test was used at a significance level of 0.05...

Results: The results showed that running exercise has a significant effect on the hippo-campus neuron density of rats, and the (AT) group showed higher neuronal density than the (C) group. But, there is no significant effect of running exercise on the thick-ness of the pyramidal layer of the hippocampus of rats in the (AT) group and differ-ences between (AT) and (AC) groups was not significant.

Conclusion: The use of running activity can increase the overall neuronal density of the hippocampus and thus help improve memory performance in Alzheimer's patients.


Main Subjects