Sport Biosciences

The Effect of Moderate Resistance Training on Lymphocyte Cells ABCA1 Gene Expression, HDL and LDL in male with Coronary Artery Disease

Document Type : Research Paper

Authors

Alireza Hajighasemi 1
Ali Asghar Ravasi 2
Mohammad Reza Kordi 3
Amir Rashidlamir 4

1 Department of Sport Biosciences, Alborz campus, Tehran University, Tehran, Iran.

2 Corresponding Author, Department of Sport Biosciences, Faculty of Physical Education and Sport Sciences, University of Tehran,

3 Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.

4 Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.

https://doi.org/10.22059/jsb.2022.206134.1075
Abstract
Introduction: : One of the most important causes of cardiovascular diseases is atherosclerosis. Arteriosclerosis or atherosclerosis is the name of a disease in the vascular system, especially in the coronary arteries of the brain and heart, which is characterized by the deposition of lipids and other substances on the inner wall of the vessels. Atherosclerosis is the most important cause of death in the world. ABCA1 is the main responsible for the removal of cholesterol and phospholipid from the cell and the formation of HDL particles, and probably plays a role in the prevention and prevention of the spread of atherosclerosis. The aim of this study is the effect of cardiac rehabilitation training on ABCA1 gene expression.
Methods: Twentythree Myocardial infractions patients were randomly selected and assigned into two groups: control (N=11), and experimental (N=12). Blood sample of subjects were collected before and after exercise sessions. PBMN cells were separated and m-RNA purification was performed by Real–Time PCR. Data was analyzed by ANCOVA by SPSS software.
Results: Rehabilitation exercises increased ABCA1 gene expression and did not change HDL, LDL and RF ratio(P≤0.05).
Conclusion: In the end, the results of the research showed that cardiac rehabilitation exercises, which consisted of aerobic and light resistance exercises, in patients with arteriosclerosis, low intensity exercises caused a significant increase in ABCA1 gene expression in arteriosclerosis patients after 8 weeks, which probably It can be effective in reverse transfer of cholesterol and prevention of subsequent ischemia.

Keywords

ABCA1 gene
MI Gene
PBMN Gene
Resistance Exercise
Reverse Cholesterol Transport

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  • Receive Date 15 May 2016
  • Revise Date 20 August 2016
  • Accept Date 22 August 2016

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