Sport Biosciences

The Effect of Endurance Training on SYD Gene Expression in Motor Neurons of Rats with Diabetic Neuropathy

Document Type : Research Paper

Authors

Maryam Fouladvand
Reza Gharakhanlou 1
Ahmad Hematfar 2
Masoud Rahmati 3

1 Associate Professor, Department of Exercise Physiology, Tarbiat Modares University, Tehran, Iran

2 Assistant Professor, Department of Exercise Physiology, Islamic Azad University, Borujerd Branch, Borujerd, Iran

3 Assistant Professor, Department of Physical Education, Lorestan University, Khoramabad, Iran

https://doi.org/10.22059/jsb.2017.60977
Abstract
 
The aim of the present study was to investigate the effect of endurance training on SYD gene expression in motor neurons of rats with diabetic neuropathy. 12 Wistar male rats were randomly assigned to 3 groups (each group 4 subjects): diabetic trained (DT), diabetic untrained (DC) and healthy control (HC). Two weeks after STZ injection to induce diabetes, diabetic neuropathy was demonstrated by behavioral tests and endurance training protocol was performed. Then, L4-L6 motor neurons of spinal cord tissue were removed, and SYD gene expression was analyzed with Real time-PCR methods. The findings showed that mean SYD gene expression in DC group was significantly higher than HC group. Also, SYD gene expression in DT group was significantly lower than DC group. Generally, it can be concluded that in motor neurons of diabetic rats, mRNA SYD up-regulation is involved in neuronal injury signaling and training as a non-pharmacotherapy strategy can modulate it and get it close to normal levels.

Keywords

diabetic neuropathy
Endurance training
gene expression
SYD
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Sport Biosciences
Volume 8, Issue 4 - Serial Number 4
Winter 2017
Pages 480-465

  • Receive Date 17 March 2014
  • Revise Date 09 November 2014
  • Accept Date 09 November 2014

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