Effect of Eight Weeks High Intensity Interval Training on Gene Expression of PGC-1α, in Male Healthy Rats Fast-Slow Twitch Muscles

Hadidi, Vahid; Kordi, Mohamadreza; Gaeini, Abasali; Nekoi, Amin; Shafie, Ahad; Hajati Modaraie, Motahareh

doi:10.22059/jsb.2015.57290

Effect of Eight Weeks High Intensity Interval Training on Gene Expression of PGC-1α, in Male Healthy Rats Fast-Slow Twitch Muscles

Document Type : Research Paper

Authors

Vahid Hadidi ¹

Mohamadreza Kordi ²

Abasali Gaeini

Amin Nekoi

Ahad Shafie

Motahareh Hajati modaraie

¹ Dept. of Sport Physiology, School of Physical Education And Sport Science, Shiraz University, Shiraz, Iran.

² Department of Exercise Physiology, Tehran University, Tehran, Iran

https://doi.org/10.22059/jsb.2015.57290

Abstract

The aim of the present study was to investigate the effect of HIIT run on PGC-1α gene expression in fast & slow twitch muscles of healthy male rats. For this purpose, 12 male Wistar rats divided into two groups: contorol (n=6) and exercise (n=6) , respectively. Intense interval training was consists of five days and a total of eight weeks, that was formed the three frequencies ( 90 to 100% VO2max intensity for four minutes and two minutes at an intensity of 50 to 60% VO2max). 24 hours after the last training session, extensor digitorum longus muscle (EDL) and soleus was extracted and relevant variables and expression levels were measured by RT-PCR. Results showed a HIIT run a significant increase PGC-1α gene expression in both muscle groups were trained (p=0/004 and p=0/001). According to the findings, implement HIIT will be increases PGC-1α and oxidative capacity in SOL and EDL muscles.

Keywords

PGC-1α

mitochondrial biogenesis

High intensity interval trainin

fast twitch muscle

slow-twitch muscles

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