Document Type : Research Paper I Open Access I Released under CC BY 4.0 license



Angiogenesis is defined as biological process of sprouting new vessels from existing vessels in tissue. Angiogenesis process is essential for Organogenesis, cell proliferation and differentiation in embryonic. This process has also been observed in adult humans and animals, which can be classified in two forms of physiological and pathophysiologic. The purpose of present research was to investigate the effect of high-intensity interval exercise (HIE) in hypoxia and normoxia conduction on response of serum VEGF in inactive men. To this end, nine inactive young men (age 24.50±5 years, height 174.22±4/6 cm, weight 70.75±4.5 kg and maximum word output (W max) in hypoxia conduction 185±29/04 and normoxia 200.00±31/8) were selected as subjects. Subjects performed protocol of high-intensity exercise in normobaric normoxia conduction (%15/3-15/5 O2 altitude of approximately 2500 m) and hypoxia in two separate weeks. Blood samples was taken immediately before and 2 hours after exercise. The ANOVA technique with repeated measures was used to analyze the data(P=0/452). Training interventions and a lot study are needed to determine angiogenesis in human body. Although high levels of VEGF after high-intensity exercise may be leading to increased angiogenesis. However, future studies are needed to determine the drivers and mechanisms that have been reported for new vascular growth in high-intensity exercise.