The Acute Effects of High Intensity Interval Training (HIIIT) on PGC-1α and FNDC5 Genes Expression in Diabetic Rats

Khalafi, Mousa; Ravasi, Ali Asghar; Soori, Rahman; Moradi, Mohammad; Soleimani, Massoud

doi:10.22059/jsb.2020.119643.902

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ PhD of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran

² Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran,

³ Professor, Department of Exercise Physiology, Faculty of Physical Education, University of Tehran, Tehran, Iran

⁴ PhD Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

⁵ Associate Professor, Tarbiat Modares University, Tehran, Iran

https://doi.org/10.22059/jsb.2020.119643.902

Abstract

Change in adipose tissue phenotype caused by exercise training is new theory that as result of muscle FNDC5 gene expression. The aim of the present study is to investigate the acute effects of high intensity interval training (HIIT( on PGC-1α and FNDC5 genes expression of diabetic rats. In this study, 18 diabetic wistar rats(12 week- age, 220-240 gr- weight) were assigned to three groups: high intensity interval training Immediately (HIIE0)(n=6), high intensity interval training 2hours later (HIIE2)(n=6) and control(C)(n=5). Both HIIT groups activated on the treadmill with 90-95% vo2max in the 12 interval-one minute period and 1 minute rest intervals. Real time PCR method was used for the relative expression of mRNA FNDC5 and PGC-1α. One-way ANOVA and Tukey Post hoc test has used to data analysis, the level of significance has been consider at 0/05. Data Analysis showed significant differences Research groups in expression of mRNA FNDC5 and PGC-1α (p≤0/01.) Tukey test showed, FNDC5 and PGC-1α gene expression In the 2 groups high intensity interval training(HIIT0-HIIT2) compared to the control group significantly increased (p≤0/01).

Keywords

References

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Journal of Sport Biosciences

The Acute Effects of High Intensity Interval Training (HIIIT) on PGC-1α and FNDC5 Genes Expression in Diabetic Rats

References

References

Volume 12, Issue 3
January 2020
Pages 249-261

The Acute Effects of High Intensity Interval Training (HIIIT) on PGC-1α and FNDC5 Genes Expression in Diabetic Rats

References

References

Volume 12, Issue 3January 2020Pages 249-261

Volume 12, Issue 3
January 2020
Pages 249-261