Evaluation of Apoptotic Regulator Markers after a Period of Increased Endurance Training in Serum of Wistar Rats with MI

Khansooz, Mojtaba; Abedi, Bahram; Palizvan, Mohammad Reza; Saremi, Abbas

doi:10.22059/jsb.2020.287398.1357

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ Ph.D. Student, Department of Physical Education, Mahallat Branch, Islamic Azad University Mahallat, Iran

² . Associate Professor, Department of Physical Education, Mahallat Branch, Islamic Azad University Mahallat, Iran

³ . professor, Department of Physiology, Arak University of Medical Sciences, Arak, Iran

⁴ Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran

https://doi.org/10.22059/jsb.2020.287398.1357

Abstract

Aim: Cardiovascular disease, due to its chronicity, often affects everyday activities of the individual and is the leading cause of death in the world. The purpose of this study was to investigate the effect of increasing endurance training on adjustment indicators Apoptosis is indicated in samples of patients with myocardial infarction.
Methodology: In this study, 20 Wistar rats aged 8-10 weeks with a mean weight of 230±30 for two groups of infarction control (Sed.MI) and infarction (Ex.MI). After induction of experimental myocardial infarction with two intraperitoneal isoproterenol injections at a dose of 150 mg/kg for 24 hours, the exercise group performed an endurance training protocol on the treadmill for eight weeks. Applying in the same conditions followed at least 24 hours after the last training session. To examine the significant changes in the levels of Caspase-3, Caspase-8 and Cytochrome-C, independent t-test was used in Graph Pad program.
Results: The results showed that serum levels of Caspase-8, cytochrome-C and Caspase 3 in Ex.MI group were higher than that of Sed.MI group. This increase was not significant in the cases of Caspase-3(p=0.65) and cytochrome-c (p=0.25) between Sed.MI and Ex.MI. But increase in caspase-8 values showed significant differences (p=0.04).
Conclusion: According to the results of this study, it seems that application of non-pharmacological strategies such as incremental endurance training cannot improve apoptosis rate in samples with myocardial infarction.

Keywords

Main Subjects

Exercise Physiology

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Journal of Sport Biosciences

Evaluation of Apoptotic Regulator Markers after a Period of Increased Endurance Training in Serum of Wistar Rats with MI

References

References

Volume 12, Issue 1
June 2020
Pages 109-126

Evaluation of Apoptotic Regulator Markers after a Period of Increased Endurance Training in Serum of Wistar Rats with MI

References

References

Volume 12, Issue 1June 2020Pages 109-126

Volume 12, Issue 1
June 2020
Pages 109-126