Effect of 12 Weeks Aerobic Training and Oral Green tea Extract on Cardiac Caspase-3 Expression in Aged Male Rats

Norouzi Kamareh, Mirza Hossein; Zolfaghari, Mohammad Reza; Ghaderi Pakdel, Firouz; Tolouei Azar, Javad

doi:10.22059/jsb.2018.245693.1220

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ PhD Student of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran.

² Department of Sport Sciences, Urmia University, Urmia, Iran

³ Associate Professor of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

https://doi.org/10.22059/jsb.2018.245693.1220

Abstract

Aim: The incidence of heart failure increases with age. Cardiomyocyte apoptosis contributes to the pathogenesis of heart failure. The aim of this study was to evaluate the effect of 12 weeks aerobic training and oral green tea extract on cardiac caspase-3 expression in aged male rats.
Methodology: In this study, 32 aged male rats were randomly divided into 4 groups: control, exercise, supplement and exercise + supplement. Exercise groups performed at intensity of 60-75% of vo2peak aerobic exercise for 12 weeks and 5 days per week; meantime, the supplementary groups consumed green tea extract. Immunohistochemistry method was used to measure the expression of caspase-3. Data was analyzed by ANOVA and Tukey's post hoc test.
Results: The results show that caspase-3 expression was significantly lower in exercise group (18%), supplement group (13%) and exercise + supplement group (43%), than the control group (p≤0.05). Also, caspase-3 expression was significantly lower in exercise + supplement group than exercise group (30%) and supplement group (34%) (p≤0.05).
Conclusion: According to the results of this of this study, combination of 12 weeks of moderate-intensity aerobic training with supplementation of green tea extract can decreased the expression of cardiac caspase-3 than aerobic training and supplementation of green tea alone.

Keywords

References

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Journal of Sport Biosciences

Effect of 12 Weeks Aerobic Training and Oral Green tea Extract on Cardiac Caspase-3 Expression in Aged Male Rats

References

References

Volume 10, Issue 2
September 2018
Pages 221-235

Effect of 12 Weeks Aerobic Training and Oral Green tea Extract on Cardiac Caspase-3 Expression in Aged Male Rats

References

References

Volume 10, Issue 2September 2018Pages 221-235

Volume 10, Issue 2
September 2018
Pages 221-235