Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
Abstract
Diabetes is a metabolic disorder specified by hyperglycemia following a defect in insulin secretion, insulin resistance or both. The aim of this study was to examine the effect of high-intensity interval training (HIIT) on serum adiponectin levels and insulin resistance of women with type 2 diabetes. For this purpose, 35 overweight women with type 2 diabetes (age range 45-60 years, BMI 25-30 kg/m2) voluntarily participated in this study and were assigned to the HIIT training group (n=17) and control group (n=18). The HIIT group conducted their training on an ergometer for 8 weeks (3 sessions per week, 4-6 30-second repetitions with highest effort and 250% intensity with 4-min. rest intervals). The results of dependent t test showed a significant decrease in the mean scores of pretest and posttest of insulin resistance and body fat percentage in HIIT group and a significant increase in mean scores of serum adiponectin levels and maximal oxygen uptake (P<0.05). The analysis of covariance showed significant differences between training and control groups in levels of adiponectin (F=3.21, P=0.026), insulin resistance (F=5.28, P=0.007) and fat percentage (F=2.60, P=0.041). Weight and body mass index of participants did not change significantly (P>0.05). It may be noted that 8 weeks of high-intensity interval training (HIIT) with no changes in weight and body mass index could have positive effects on insulin resistance, fat percentage and adiponectin levels in women with type 2 diabetes.
Keywords
- توفیقی، اصغر؛ صمدیان، زهرا (1392). مقایسۀاثر 12هفتهتمرینورزشی هوازیومقاومتیبرسطوحسرمی رزیستینو شاخص‌هایگلیسمیدرزنانیائسۀچاقمبتلابهدیابتنوع2 (مقایسۀدونوع پروتکلورزشی)، جندی‌شاپور، دورة 12 ، ش 6، ص 676 -665.
- علی‌زاده، زهرا؛ کردی، رامین؛ حسین‌زاده، محمدجواد؛ منصورنیا، محمدعلی (1390). بررسیتأثیرورزشهوازیمداومومتناوببرسطحلیپیدوقندخونناشتادر خانم‌هایدارایشاخصتودۀبدنیبالاترازkg/m2 25 ، دانشکدۀ پزشکی، دورۀ 69 ، ش 4، ص 259-253.
3. Adams, O. P. (2013). "The impact of brief high-intensity exercise on blood glucose levels". Diabetes Metab Syndr Obes., Vol. 27 No.6, PP:113-122
4. Bouassida, A., Chamari, K., Zaouali, M., Feki, Y., Zbidi, A., Tabka, Z. (2010). "Review on leptin and adiponectin responses and adaptations to acute and chronic exercise". Br J Sports Med., Vol.44 No.9, PP: 620-30.
5. Buchan, D. S,, Ollis, S., Young, J. D., Cooper, S. M., Shield, J. P., Baker, J. S. (2013). "High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents". BMC public health., Vol.13 No.1 PP:498.
6. Chen, L., Pei, J. H., Kuang, J., Chen, H. M., Chen, Z., Li, Z. W., Yang, H. Z. (2015). "Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis". Metabolism., Vol.64 No.2 PP:338-347
7. Coburn, J. W., Malek, M. H. (2011). "NSCA's Essentials of Personal Training": Human Kinetics Publishers.
8. Coker, R. H., Hays, N. P., Williams, R. H., Brown, A. D., Freeling, S. A., Kortebein, P. M., et al. (2006). "Exercise-induced changes in insulin action and glycogen metabolism in elderly adults". Med Sci Sports Exerc., Vol.38 No.3 PP:433-8.
9. Coker, R. H., Williams, R. H., Kortebein, P. M., Sullivan, D. H., Evans, W. J. (2009). "Influence of exercise intensity on abdominal fat and adiponectin in elderly adults". Metabolic syndrome and related disorders., Vol.7 No.4 PP:363-368.
10. Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., et al. (2010). "Exercise and type 2 diabetes the American College of Sports Medicine and the American Diabetes Association: joint position statement". Diabetes care., Vol.33 No.12 PP:147-167.
11. Cuff, D. J., Meneilly, G. S., Martin, A., Ignaszewski, A., Tildesley, H. D., Frohlich, J. J. (2003). "Effective exercise modality to reduce insulin resistance in women with type 2 diabetes". Diabetes care., Vol.26 No.11 PP: 2977-2982.
12-Engeli, S., Gorzelniak, K., Kreutz, R., Runkel, N., Distler, A., Sharma, A. M. (1999). "Co-expression of renin-angiotensin system genes in human adipose tissue". Journal of hypertension., Vol.17 No.4 PP:555-560.
13. Gibala, M. J. (2007). "High-intensity interval training: a time-efficient strategy for health promotion"? Current sports medicine reports., Vol.6 No.4 PP:211- 3.
14. Gibala, M. J., Little, J. P., Van, Essen. M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., et al. (2006). "Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance". The Journal of physiology., Vol. 575 No.3 PP:901-911.
15. Gist, N. H., Fedewa, M. V., Dishman, R. K., Cureton, K. J. (2014). "Sprint interval training effects on aerobic capacity: a systematic review and meta-analysis". Sports Med., Vol. 44 No.2 PP: 269-79.
16. Grediagin, M. A., Cody, M., Rupp, J., Benardot, D., Shern, R. (1995). "Exercise intensity does not effect body composition change in untrained, moderately overfat women". Journal of the American Dietetic Association., Vol. 95 No.6 PP:661-5.
17. Hovanloo, F., Arefirad, T., Ahmadizad, S. (2013). "Effects of sprint interval and continuous endurance training on serum levels of inflammatory biomarkers". J Diabetes Metab Disord., Vol.12 No.1 PP:22.
18. Huang, H., Iida, K. T., Sone, H., Yokoo, T., Yamada, N., Ajisaka, R. (2006). "The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice". Journal of endocrinology., Vol.189 No.3 PP:643-53.
19. Hulver, M. W., Zheng, D., Tanner, C. J., Houmard, J. A., Kraus, W. E., Slentz, C. A, et al. (2002). "Adiponectin is not altered with exercise training despite enhanced insulin action". American Journal of Physiology-Endocrinology and Metabolism., Vol.283 No.4 PP:861-865.
20. Jorsal, A., Tarnow, L., Frystyk, J., Lajer, M., Flyvbjerg, A., Parving, H. H, Vionnet, N., Rossing, P.( 2008). "Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy". Kidney Int., Vol.74 No.5 PP: 649-654.
21. Kraemer, R. R., Aboudehen, K. S., Carruth, A. K., Durand, R. J., Acevedo, E. O., Hebert, E. P., et al. (2003). "Adiponectin responses to continuous and progressively intense intermittent exercise". Medicine and Science in Sports and Exercise., Vol.35 No.8 PP:1320-1325.
22. Kraemer, R. R., Castracane, V. D. (2007). "Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin". Experimental biology and medicine., Vol.232 No.2 PP:184-194.
23. Larose, J., Sigal, R., Khandwala, F., Kenny, G. (2012). "Comparison of strength development with resistance training and combined exercise training in type 2 diabetes". Scandinavian journal of medicine & science in sports., Vol. 22 No.4 PP:45-54.
24. Lee, S. H., Hong, H. R., Han, T. K., Kang, H. S. (2015). "Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men". Biol Sport Sep., Vol. 32 No.3 PP:181-186.
25. Leggate, M., Carter, W. G., Evans, M. J, Vennard, R. A., Sribala-Sundaram, S., Nimmo, M. A. (2012). " Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males ". Journal of Applied Physiology., Vol. 112 No.8 PP:1353-60.
26. McCormack, S. E., McCarthy, M. A., Harrington, S. G., Farilla, L., Hrovat, M. I., Systrom, D. M., Thomas, B. J. (2014). "Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents". Pediatric ObeHITy., Vol.9 No.4 PP: 281–291.
27. Neil Thomas, G., Q Jiang, C., Taheri, S., H Xiao, Z., Tomlinson, B., MY Cheung, B., et al. (2010). "A systematic review of lifestyle modification and glucose intolerance in the prevention of type 2 diabetes". Current diabetes reviews., Vol.6 No.6 PP:378-387.
28. Ohashi, K., Shibata, R., Murohara, T., Ouchi, N. (2014). "Role of anti-inflammatory adipokines in obeHITy-related diseases". Trends in endocrinology and metabolism: TEM., Vol.25 No.7 PP: 348-355.
29. Pavkov, M. E., Bennett, P. H., Knowler, W. C., Krakoff, J., Sievers, M. L., Nelson, R. G. (2006). "Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians". Jama., Vol.296 No.4 PP:421-426.
30. Rawal, L. B., Tapp, R. J., Williams, E. D., Chan, C., Yasin, S., Oldenburg, B. (2012). "Prevention of type 2 diabetes and its complications in developing countries: a review". International journal of behavioral medicine., Vol.19 No.2 PP:121-133.
31. Ryan, A. S., Nicklas, B. J., Berman, D. M., Elahi, D. (2003). "Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women". International journal of obeHITy., Vol.27 No.9 PP:1066-1071.
32. Simpson, K. A., Singh, M. A. F. (2008). "Effects of exercise on adiponectin: a systematic review". ObeHITy., Vol.16 No.2 PP:241-56.
33. Simpson, S. H., Corabian, P., Jacobs, P., Johnson, J. A. (2003). "The cost of major comorbidity in people with diabetes mellitus". Canadian Medical Association Journal., Vol.168 No.13 PP:1661-1667.
34. Shing, C. M., Webb, J. J., Driller, M. W., Williams, A. D., Fell, J. W. (2013). "Circulating adiponectin concentration and body composition are altered in response to high-intensity interval training". The Journal of Strength & Conditioning Research., Vol.27 No.8 PP:2213-8.
35.Talanian, J. L., Galloway, S. D., Heigenhauser, G. J., Bonen, A., Spriet, L. L. (2007). "Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women". Journal of applied physiology., Vol.102 No.4 PP:1439-47.
36. Trapp, E., Chisholm, D., Freund, J., Boutcher, S. (2008). "The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women". International Journal of ObeHITy., Vol.32 No.4 PP:684-91.
37. Wannamethee, S. G., Lowe, G. D. O., Rumley, A., Cherry, L., Whincup, P. H., Sattar, N. (2007) "Adipokines and risk of type 2 diabetes in older men". Diabetes care., Vol.30 No.5 PP:1200-1205.
38. Zhang, Y., Zhang, Y., Mills, P. J., Rehman, J. (2006). "Dynamic Exercise Can Acutely Increase Circulating Adiponectin". Circulation., Vol.114 No.18 PP: 881.
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