This study aimed to assess the effects of four weeks of detraining after eight weeks of intense sprint training on risk factors of atherogenic inflammatory damages. For this purpose, 42 male rats were divided randomly into two groups: sprint training group (experimental) (n=24 and weight 210±7) and control group (n=18 and weight 211±3). The training program was performed for 12 weeks, three sessions per week with definite duration and speed (between %80-%100 and above 100% VO2max). After 24 sessions, six trained rats experienced the detraining, so the effects of detraining could be studied. The blood samples were gathered after 14 hours of fasting in different phases of training. Data were analyzed by Kolmogorov-Smirnov, one-way ANOVA with repeated measures, LSD post hoc and independent t tests. The results indicated that after 36 sessions of training, sICAM-1 (P=0.004), IL-1? (P=0.023) and TNF-? (P=0.040) increased significantly. Also, following four weeks of detraining after eight weeks of intense sprint training, inflammatory biomarkers of sICAM-1 (P=0.152), IL- IL-1? (P=0.063) & TNF-a (P=0.099) insignificantly decreased, but they were significant compared with the training group sICAM-1 (P=0.024), IL-1? (P=0.037) and TNF-a (P=0.018). In general, it can be concluded that four weeks of detraining after an intense sprint training lead to a decline in risk factors of atherogenic inflammatory damages.