نشریه علوم زیستی ورزشی

تأثیر دوازده هفته تمرین هوازی بر سطوح سرمی پروتئین شبه‌آنژیوپیتین4 و بتا آمینو ایزوبوتیریک اسید در مردان مبتلا به سندروم متابولیک

نوع مقاله : مقاله پژوهشی

نویسندگان

ریحانه عارفی شیروان 1
بهلول قربانیان 2
بهروز قربان زاده 1

1 فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکدۀ علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.

2 نویسندۀ مسؤول، فیزیولوژی ورزشی، گروه علوم ورزشی، دانشکدۀ علوم تربیتی و روان‌شناسی، دانشگاه شهید مدنی آذربایجان، تبریز، ایران.

https://doi.org/10.22059/jsb.2023.349902.1556
چکیده
مقدمه: سندروم متابولیک، اختلال متابولیک شایعی است که در نتیجۀ شیوع چاقی ایجاد می‌شود. بررسی‌ها نشان می‌دهد بتا آمینو ایزوبوتیریک در تنظیم سوخت‌وساز لیپید و کربوهیدراتر بافت چربی، کبد و عضلات اسکلتی و پروتئین شبه‌آنژیوپیتین4 در سوخت‌وساز چربی نقش دارد و کنترل متابولیک را تعدیل می‌کند. هدف این تحقیق بررسی تأثیر 12 هفته تمرین هوازی بر سطوح سرمی پروتئین شبه‌آنژیوپیتین4 و بتا آمینو ایزوبوتیریک در مردان مبتلا به سندروم متابولیک بود.
روش پژوهش: در این تحقیق نیمه‌تجربی با طرح پیش‌آزمون - پس‌آزمون 20 نفر از افراد دارای شرایط کامل ابتلا به سندروم متابولیک با دامنۀ سنی 40-60 سال به‌صورت تصادفی به گروه‌های کنترل و تجربیگروه کنترل 10 نفر و تمرین هوازی 10 نفر) تقسیم شدند. مدت فعالیت ورزشی هوازی برای این بیماران مساوی یا بیشتر از 30 دقیقه در هر جلسه بود؛ دورۀ 45 دقیقه‌ای همراه با 15 دقیقه گرم و سرد کردن بود که با شدت متوسط و توالی سه جلسه در هفته به مدت 12 هفتۀ متوالی انجام گرفت. اندازه‌گیری متغیرهای خونی برای غلظت سرمی پروتئین شبه‌آنژیوپیتین4 و بتا آمینو ایزوبوتیریک و همچنین شاخص‌های خطر متابولیک در مرحلۀ پیش‌آزمون و پس‌آزمون سنجش شد. به‌منظور بررسی تفاوت میانگین بین گروه‌ها در مراحل پیش و پس از مداخلۀ تمرین از آزمون‌های تی مستقل و برای مقایسۀ میانگین گروه‌ها در مراحل پیش‌آزمون و پس‌آزمون از آزمون تی و آزمون آنکوا استفاده شد.
یافته‌ها: در اثر اعمال مداخلۀ تمرین در گروه تجربی مقادیر متغیرهای بتا آمینو ایزوبوتیریک (0.001=P)، حداکثر اکسیژن مصرفی (0.001=‌P) و لیپوپروتئین پرچگال (0.001=‌P) افزایش معنادار و پروتئین شبه‌آنژیوپیتین4 (0.001=P)، چربی بدن (0.001=P)، ‌ شاخص تودۀ بدن (0.033=P)، اندازۀ دور کمر (0.01=P)، تری‌گلیسیرید (0.015=P)، لیپوپروتئین کم‌چگال ‌(0.009=P)، کلسترول تام (0.033=P) و انسولین (0.001=P) کاهش معنادار در گروه تجربی نسبت به گروه کنترل داشتند (0.05>P).
نتیجه‌گیری: تمرین هوازی را به‌دلیل تأثیر مثبت بر سطوح سرمی پروتئین شبه‌آنژیوپیتین4 و بتا آمینو ایزوبوتیریک و همچنین تأثیر بر عوامل مرتبط با خطر متابولیک می‌توان به‌عنوان روشی برای فعال‌سازی مسیر تبدیل چربی سفید به قهوه‌ای و بهبود شاخص‌های مربوط به خطر متابولیک برای مردان مبتلا به سندروم متابولیک پیشنهاد کرد.

کلیدواژه‌ها

تمرینات هوازی
پروتئین شبه آنژیوپیتین4
بتا آمینو ایزوبوتیریک اسید
سندرم متابولیک
موضوعات

عنوان مقاله English

The Effect of Twelve Weeks of Aerobic Exercise on the Serum Levels of Angiopoietin-Like Protein 4 (Angptl4) and Beta-Aminoisobutyric Acid (BAIBA) in Men with Metabolic Syndrome

نویسندگان English

Reyhaneh Arefi shirvan 1
Bahloul Ghorbanian 2
Behrouz Ghorbanzadeh 1
1 Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
2 Corresponding Author, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
چکیده English

Introduction: Metabolic syndrome is a common metabolic disorder that occurs as a result of the prevalence of obesity. Studies showed that Beta-Aminoisobutyric Acid (BAIBA) plays a role in the regulation of lipid and carbohydrate metabolism in adipose tissue, liver, and skeletal muscles, and Angiopoietin-Like Protein 4 (ANGPTL4) plays a role in lipid metabolism and modulates metabolic control. This study aimed to investigate the effect of 12 weeks of aerobic training on ANGPTL4 and BAIBA serum levels in men with metabolic syndrome.
Methods: In this quasi-experimental study with a pre-test-post-test design, 20 people with whole conditions of metabolic syndrome, and with an age range of 40-60 years old were randomly divided into Control and Experimental groups (10 people in each group). The duration of aerobic exercise for these patients was more than or equal to 30 minutes in each session. The period was 45 minutes with 15 minutes of warm-up and cool-down, which was performed with moderate intensity and a sequence of three sessions per week for 12 consecutive weeks. Blood variables for ANGPTL4, and BAIBA serum concentration as well as metabolic risk indices were measured in the pre-test and post-test phases. Independent t-tests were used to examine the mean difference between the groups, pre- and post-exercise intervention, and t-tests and ANCOVA tests were used to compare the mean groups in each pre-test and post-test phase.
Results: As a result of exercise intervention in the experimental group, the amounts of BAIBA (P=0.001), VO2max (P=0.001), and ‌HDL (P=0.001) increased significantly; however, ANGPTL4 (P=0.001), BF (P=0.001), BMI (P=0.033), waist size (P=0.01), TG (P=0.015) LDL (P=0.009), TC (P=0.033) and insulin (P=0.001) decreased significantly in the exercise group compared with the control group (P<0.05).
Conclusion: Due to its positive effect on the serum levels of ANGPTL4, and BAIBA and also its effect on factors related to metabolic risk, aerobic training can be used as a method to activate the pathway of white to brown lipid conversion and improve indicators related to metabolic risk for men with metabolic syndrome.

کلیدواژه‌ها English

Aerobic exercise
ANGPTL4
BAIBA
Metabolic syndrome
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  • تاریخ دریافت 24 مهر 1401
  • تاریخ بازنگری 01 دی 1401
  • تاریخ پذیرش 11 دی 1401

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