University of Tehran Press Sport Biosciences 2008-9325 16 2 2024 08 22 The Effect of Ginkgo Biloba Supplementation and Interval Endurance Training on Activity of TNF-α and BDNF in Hippocampus of Male Alzheimer's Model Rats The Effect of Ginkgo Biloba Supplementation and Interval Endurance Training on Activity of TNF-α and BDNF in Hippocampus of Male Alzheimer's Model Rats 31 42 98727 10.22059/jsb.2024.375361.1631 FA Fatemeh Parsifar Department of Physical Education, Faculty of Educational Sciences, University of Sistan and Baluchestan, Zahedan, Iran. 0000-0001-6169-3267 Majid Vahidian-Rezazadeh Department of Physical Education, National University of Skills (NUS), Tehran, Iran 0000-0001-7280-4188 Zahra Jahantigh Department of Physical Education, Faculty of Educational Sciences, University of Sistan and Baluchestan, Zahedan, Iran. 0000-0002-3818-0073 Amir Hosein Rakhshani Department of Physical Education, Faculty of Educational Sciences, University of Sistan and Baluchestan, Zahedan, Iran. 0000-0002-9886-3642 Journal Article 2024 05 23 Introduction: Alzheimer's disease (AD) is one of the neurodegenerative diseases associated with cognitive decline and inflammation. The aim of this study was to the effect of ginkgo biloba supplement and intermittent endurance training on serum TNF-α and BDNF activity in male Alzheimer's model tats.<br />Methods: For this purpose, 50 male Wistar rats were divided into seven control groups (n=8), Alzheimer's control group (n=8), placebo group (n=5), sham group (five heads), Alzheimer's + exercise group (n=8), Alzheimer's group + supplement (eight heads) and Alzheimer group + supplement and exercise (eight heads) were divided. Intermittent endurance training was performed for eight weeks, five days a week. The receiving animals received 100 mg/kg supplement by gavage for five days a week. The Alzheimer's model was induced by injecting beta-amyloid into both sides of the ventricles of the animals' brains. To check the results of Lon's test to check the homogeneity of the data, a one-way analysis of variance test was performed to check the difference between the groups at the significance level of P < 0.05 using SPSS22 software.<br />Results: The results of the one-way analysis of variance test showed that there is no significant difference between BDNF and TNF-α levels in the serum of male Alzheimer's model rats (P<0.05).<br />Conclusion: Considering that the levels of BDNF and TNF-α are found in the peripheral brain and nerves and play an important role in neuronal protection and neurogenesis, periodic endurance training did not affect their levels in the serum of male Alzheimer's model rats. Introduction: Alzheimer's disease (AD) is one of the neurodegenerative diseases associated with cognitive decline and inflammation. The aim of this study was to the effect of ginkgo biloba supplement and intermittent endurance training on serum TNF-α and BDNF activity in male Alzheimer's model tats.<br />Methods: For this purpose, 50 male Wistar rats were divided into seven control groups (n=8), Alzheimer's control group (n=8), placebo group (n=5), sham group (five heads), Alzheimer's + exercise group (n=8), Alzheimer's group + supplement (eight heads) and Alzheimer group + supplement and exercise (eight heads) were divided. Intermittent endurance training was performed for eight weeks, five days a week. The receiving animals received 100 mg/kg supplement by gavage for five days a week. The Alzheimer's model was induced by injecting beta-amyloid into both sides of the ventricles of the animals' brains. To check the results of Lon's test to check the homogeneity of the data, a one-way analysis of variance test was performed to check the difference between the groups at the significance level of P < 0.05 using SPSS22 software.<br />Results: The results of the one-way analysis of variance test showed that there is no significant difference between BDNF and TNF-α levels in the serum of male Alzheimer's model rats (P<0.05).<br />Conclusion: Considering that the levels of BDNF and TNF-α are found in the peripheral brain and nerves and play an important role in neuronal protection and neurogenesis, periodic endurance training did not affect their levels in the serum of male Alzheimer's model rats. https://jsb.ut.ac.ir/article_98727_6219bf4102242a07bd1f7688ce097b14.pdf