University of Tehran Press Sport Biosciences 2008-9325 16 2 2024 08 22 The effect of running on a Complex wheel running on hippocampal histology and memory function in Alzheimer's disease model rats. The effect of running on a Complex wheel running on hippocampal histology and memory function in Alzheimer's disease model rats. 17 29 98726 10.22059/jsb.2024.369150.1620 FA Nadia Tajevanchi Department of Exercise Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Rasol Hashem Kandi Asadi Department of Exercise Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Roghayeh Pouzesh Jadidi Department of Exercise Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Farzad Zehsaz Department of Exercise Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Journal Article 2024 01 30 <strong>Introduction:</strong> This study aimed to investigate the effect of running on a complex running wheel on hippocampus histology and memory function in rats model of Alzheimer's disease.<br /><strong>Methods:</strong> 24 rats were randomly selected and divided into three control (C), Alzheimer's control (AC), and Alzheimer's + complex wheel training (AT). To induce Alzheimer's disease in Alzheimer's groups, a mixture of ketamine (60 mg/kg) and xylazine (8 mg/kg) was injected into the hippocampus of rats. The AT group ran for 12 weeks on a complex running wheel, while the control groups (C and AC) were kept in cages for 12 weeks and did not participate in any training. In this research, the Tmaz test was used to test the spatial memory of rats. To analyze the data, a one-way analysis of variance was used at a significance level of 0.05.<br /><strong>Results:</strong> The results showed that running training has a significant effect on the hippocampal neuron density of rats. AT group showed higher neuron density than the C group. However, running training did not have a significant effect on the thickness of the hippocampal pyramidal layer of rats in the AT group, also, the difference between the AT and AC groups was not significant.<br /><strong>Conclusion:</strong> Running activity can increase the overall neuronal density of the hippocampus and thus help improve memory function in Alzheimer's patients. <strong>Introduction:</strong> This study aimed to investigate the effect of running on a complex running wheel on hippocampus histology and memory function in rats model of Alzheimer's disease.<br /><strong>Methods:</strong> 24 rats were randomly selected and divided into three control (C), Alzheimer's control (AC), and Alzheimer's + complex wheel training (AT). To induce Alzheimer's disease in Alzheimer's groups, a mixture of ketamine (60 mg/kg) and xylazine (8 mg/kg) was injected into the hippocampus of rats. The AT group ran for 12 weeks on a complex running wheel, while the control groups (C and AC) were kept in cages for 12 weeks and did not participate in any training. In this research, the Tmaz test was used to test the spatial memory of rats. To analyze the data, a one-way analysis of variance was used at a significance level of 0.05.<br /><strong>Results:</strong> The results showed that running training has a significant effect on the hippocampal neuron density of rats. AT group showed higher neuron density than the C group. However, running training did not have a significant effect on the thickness of the hippocampal pyramidal layer of rats in the AT group, also, the difference between the AT and AC groups was not significant.<br /><strong>Conclusion:</strong> Running activity can increase the overall neuronal density of the hippocampus and thus help improve memory function in Alzheimer's patients. https://jsb.ut.ac.ir/article_98726_cc305005965c1d092eaf8a45cdaf8955.pdf