University of Tehran Press Sport Biosciences 2008-9325 12 4 2021 01 20 The Effects of Endurance Training with Stanozolol Treatment on hepatic enzymes of Male Rats The Effects of Endurance Training with Stanozolol Treatment on hepatic enzymes of Male Rats 375 389 80314 10.22059/jsb.2021.231786.1169 FA Alireza Joneidi Shariatzade . PhD Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran Abbasali Gaeini . Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran 0000-0002-8679-0669 Sirous Choobineh . Associate Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran 0000-0003-4466-0986 Maryam Mirzaei PhD Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Gilan, Iran Journal Article 2017 04 22 The purpose of this study was to investigate the effects of six weeks endurance training and treatment of stanozolol on hepatic enzymes (ALT, AST and ALP) in male healthy rats. For this reason, 32 male Wistar rats aged 12 weeks old (initial body weight, 289±16g) were divided randomly into four groups; placebo (P, n=8), exercise (E, n=8), exercise stanozolol (ES, n=8) and stanozolol (S, n=8). ES and S groups received a weekly intramuscular injection (5mg/kg of body weight) of stanozolol, while P and E groups received Arashiz oil as placebo. E and ES groups were submitted to a progressive running program on a treadmill, for 6 weeks and 5 days per week. ALT, AST and ALP serum levels were measured by ELISA method. Data were analysed by one way ANOVA test, (p < 0.05). ALT (P=0.002) and AST (P=0.001) changes were significant but ALP changes were not significant. According to the findings of this study, endurance training could not modulate possible side effects of stanozolol on liver tissue. The purpose of this study was to investigate the effects of six weeks endurance training and treatment of stanozolol on hepatic enzymes (ALT, AST and ALP) in male healthy rats. For this reason, 32 male Wistar rats aged 12 weeks old (initial body weight, 289±16g) were divided randomly into four groups; placebo (P, n=8), exercise (E, n=8), exercise stanozolol (ES, n=8) and stanozolol (S, n=8). ES and S groups received a weekly intramuscular injection (5mg/kg of body weight) of stanozolol, while P and E groups received Arashiz oil as placebo. E and ES groups were submitted to a progressive running program on a treadmill, for 6 weeks and 5 days per week. ALT, AST and ALP serum levels were measured by ELISA method. Data were analysed by one way ANOVA test, (p < 0.05). ALT (P=0.002) and AST (P=0.001) changes were significant but ALP changes were not significant. According to the findings of this study, endurance training could not modulate possible side effects of stanozolol on liver tissue. https://jsb.ut.ac.ir/article_80314_f9f022216044e11ace2fd9ee1f72dce5.pdf