University of Tehran Journal of Sport Biosciences 2008-9325 12 1 2020 05 21 Preventive Effect six Weeks of Swimming Training on the Levels of Cytokines and Brain-Derived Neurotrophic Rat Model of EAE Preventive Effect six Weeks of Swimming Training on the Levels of Cytokines and Brain-Derived Neurotrophic Rat Model of EAE 53 65 76775 10.22059/jsb.2019.246687.1223 FA Sayd Mojtaba Hoseini PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran Ziya Falah Mohammadi . Associate Professor PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran Vahid Talebi PhD student of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran Journal Article 2018 01 22 Multiple sclerosis is a progressive and chronic autoimmune disease of the central nervous system that is associated with the destruction of the myelin sheath of nerve cells. The aim of this study was to investigate the preventive effect of six weeks of forced swimming on the levels of TNF-α, IL-10 and BDNF is the EAE model rats. Twenty-five female Lewis were divided into five groups: healthy control, MS control, healthy swimming, MS swimming, and solvent. Swimming training for 6 weeks and 5 days a week. Swimming training program began with 30 minutes daily five-minute period in the second week with an increase to 60 minutes. Overload training was set by adjusting the power and speed of the water while swimming. Also, EAE was induced model at the end of the sixth week of training and After 14 days’ mice were sacrificed. Right Cerebral hemisphere for the histology and right Cerebral hemisphere was transferred to the lab for analysis of protein measurements. Swimming exercise in rats EAE model leads to a significant reduction in TNF-α (P=0/001) and no significant change in IL-10 (P=0/71) and BDNF (P=0/70) was. In rats trained clinical signs appeared delayed. Furthermore, results of histological staining showed that certain differences were observed between trained and untrained. EAE-induced demyelination model increases the damage to brain tissue Shows that swimming exercise intensity and duration of six weeks can be effective in delaying symptoms, although these symptoms are delayed in the short term. Multiple sclerosis is a progressive and chronic autoimmune disease of the central nervous system that is associated with the destruction of the myelin sheath of nerve cells. The aim of this study was to investigate the preventive effect of six weeks of forced swimming on the levels of TNF-α, IL-10 and BDNF is the EAE model rats. Twenty-five female Lewis were divided into five groups: healthy control, MS control, healthy swimming, MS swimming, and solvent. Swimming training for 6 weeks and 5 days a week. Swimming training program began with 30 minutes daily five-minute period in the second week with an increase to 60 minutes. Overload training was set by adjusting the power and speed of the water while swimming. Also, EAE was induced model at the end of the sixth week of training and After 14 days’ mice were sacrificed. Right Cerebral hemisphere for the histology and right Cerebral hemisphere was transferred to the lab for analysis of protein measurements. Swimming exercise in rats EAE model leads to a significant reduction in TNF-α (P=0/001) and no significant change in IL-10 (P=0/71) and BDNF (P=0/70) was. In rats trained clinical signs appeared delayed. Furthermore, results of histological staining showed that certain differences were observed between trained and untrained. EAE-induced demyelination model increases the damage to brain tissue Shows that swimming exercise intensity and duration of six weeks can be effective in delaying symptoms, although these symptoms are delayed in the short term. https://jsb.ut.ac.ir/article_76775_eefc320b088a6b613c683ef3c47c9106.pdf