University of Tehran Press Sport Biosciences 2008-9325 12 2 2020 08 22 A Comparison of the Effect of High Intensity Interval Training and School –Based Training on has-miR125a-5p, CRP and Lipid Profile of Overweight and Obese Adolescents A Comparison of the Effect of High Intensity Interval Training and School –Based Training on has-miR125a-5p, CRP and Lipid Profile of Overweight and Obese Adolescents 173 187 76480 10.22059/jsb.2020.293458.1369 FA Sadegh Valipoor PhD Student, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran Vazgan Minasian Associate Professor, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran Silva Hovsepian Assistant Professor, Child Growth and Development Research Center, Imam Hossein Children's Hospital, Isfahan, Iran Journal Article 2019 12 04 Endothelial dysfunction is an early indicator of cardiac diseases, and loss of normal homeostatic function in the blood vessels. The aim of this study was to compare the effect of school-based and high intensity interval training on miR125a-5p, C-reactive protein and lipid profile of overweight and obese adolescents. 45 overweight and obese male students (mean age 14±1 years, body mass index 26.43±2.17 kg/m²) were voluntarily divided into three equal groups: school-based training, high intensity interval training and control. Subjects participated in the training for12 weeks and 3 sessions per week. Changes of circulating miR125a-5p, C-reactive protein and lipid profile were measured before and after the training interventions. Findings revealed that C-reactive protein, body mass index, WHR, body fat percentage, low-density lipoprotein, and triglyceride of experimental subjects decreased compared with the control group (P≤0.05). There were significant increases in the VO₂peak and high density lipoprotein levels of subjects (P=0.001), but the differences between experimental groups were not significant in both variables (P=0.15). Also, there was a significant increase in the levels of miR125a-5p, and the difference between the experimental groups was significant (P=0.001). Generally, it seems that both types of training improved the endothelial function and lipid profile, but school-based training is relatively more effective in adolescents. Therefore, based on the difficult nature of high intensity interval training for obese children, further use of school-based training is suggested. Endothelial dysfunction is an early indicator of cardiac diseases, and loss of normal homeostatic function in the blood vessels. The aim of this study was to compare the effect of school-based and high intensity interval training on miR125a-5p, C-reactive protein and lipid profile of overweight and obese adolescents. 45 overweight and obese male students (mean age 14±1 years, body mass index 26.43±2.17 kg/m²) were voluntarily divided into three equal groups: school-based training, high intensity interval training and control. Subjects participated in the training for12 weeks and 3 sessions per week. Changes of circulating miR125a-5p, C-reactive protein and lipid profile were measured before and after the training interventions. Findings revealed that C-reactive protein, body mass index, WHR, body fat percentage, low-density lipoprotein, and triglyceride of experimental subjects decreased compared with the control group (P≤0.05). There were significant increases in the VO₂peak and high density lipoprotein levels of subjects (P=0.001), but the differences between experimental groups were not significant in both variables (P=0.15). Also, there was a significant increase in the levels of miR125a-5p, and the difference between the experimental groups was significant (P=0.001). Generally, it seems that both types of training improved the endothelial function and lipid profile, but school-based training is relatively more effective in adolescents. Therefore, based on the difficult nature of high intensity interval training for obese children, further use of school-based training is suggested. https://jsb.ut.ac.ir/article_76480_9009678f7819e789dcf07d95f987b01c.pdf