University of Tehran Press Sport Biosciences 2008-9325 9 2 2017 08 23 Short-Term Effect of Two Types of High-Intensity Interval Training on Plasma Level of TNF-α, IL-6, CRP and Lipid Profile of Overweight Women Short-Term Effect of Two Types of High-Intensity Interval Training on Plasma Level of TNF-α, IL-6, CRP and Lipid Profile of Overweight Women 195 207 63447 10.22059/jsb.2017.128575.963 FA Mohammad Shariatzadeh Assistant Professor, Sport Sciences Research Institute of Iran, Tehran, Iran Zeynab Moghadam M.Sc. of Exercise Physiology, Islamic Azad University, Karaj Branch Leila Maleki M.Sc. of Exercise Physiology, Islamic Azad University, Damghan Branch Elham Keshavarz M.Sc. of Exercise Physiology, Islamic Azad University, Sari Branch Mehdi Hedayati Associate Professor in Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Journal Article 2015 07 23 The aim of this study was to investigate the effect of 4 weeks of high-intensity interval training with weight-bearing and non-weight bearing on inflammatory markers of TNF-α, IL-6, CRP and lipid profile as predictive factors of the risk of cardiovascular diseases in overweight women. 16 non-athlete women (age 30 ± 5 yr, weight 75.48 ± 13.11 kg, height 165.50 ± 2.59 cm and body mass index 27.73 ± 4.20 Kg/m2) voluntary participated in the study. Subjects were randomly divided into two groups of high-intensity interval training: anaerobic RAST test and Wingate anaerobic test for 4 weeks, 3 sessions per week (between 3 and 6 Wingate test or RAST test each session). 24 hours before and 24 hours after training, blood samples was collected and the results were analyzed with Kolmogorov-Smirnov test, covariance analysis and paired t test at a significance level of P<0.05. The results indicated a significant reduction of plasma levels of TNF-α, IL-6 and CRP and an improvement in the lipid profile (excluding HDL-C) in both groups compared with the period before the training (P<0.05). However, after 12 sessions of training no significant difference was observed in inflammatory markers and lipid profile between the two group (P<0 .05). These findings suggest that even short periods of high-intensity interval training can reduce inflammatory markers associated with cardiovascular diseases although weight-bearing or non-weight bearing types of training do not make a significant difference. The aim of this study was to investigate the effect of 4 weeks of high-intensity interval training with weight-bearing and non-weight bearing on inflammatory markers of TNF-α, IL-6, CRP and lipid profile as predictive factors of the risk of cardiovascular diseases in overweight women. 16 non-athlete women (age 30 ± 5 yr, weight 75.48 ± 13.11 kg, height 165.50 ± 2.59 cm and body mass index 27.73 ± 4.20 Kg/m2) voluntary participated in the study. Subjects were randomly divided into two groups of high-intensity interval training: anaerobic RAST test and Wingate anaerobic test for 4 weeks, 3 sessions per week (between 3 and 6 Wingate test or RAST test each session). 24 hours before and 24 hours after training, blood samples was collected and the results were analyzed with Kolmogorov-Smirnov test, covariance analysis and paired t test at a significance level of P<0.05. The results indicated a significant reduction of plasma levels of TNF-α, IL-6 and CRP and an improvement in the lipid profile (excluding HDL-C) in both groups compared with the period before the training (P<0.05). However, after 12 sessions of training no significant difference was observed in inflammatory markers and lipid profile between the two group (P<0 .05). These findings suggest that even short periods of high-intensity interval training can reduce inflammatory markers associated with cardiovascular diseases although weight-bearing or non-weight bearing types of training do not make a significant difference.

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