University of Tehran Press Sport Biosciences 2008-9325 17 4 2026 02 20 The Effects of HIIT Training and Eryngium Supplementation on Metabolic and Antioxidant Indices in Male Diabetic Rats The Effects of HIIT Training and Eryngium Supplementation on Metabolic and Antioxidant Indices in Male Diabetic Rats 59 76 104872 10.22059/jsb.2025.403708.1688 FA Ghassan Amer Bedno Department of exercise physiology and corrective movements, Faculty of Sport Sciences, Urmia University, Urmia, Iran. 0009-0009-6913-2734 Asghar Tofighi professor of exercise physiology, Urumia University, urumia, Iran 0000-0003-3626-1782 Bahram Jamali Department of Basic Sciences, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. 0000-0002-3138-273X Mohammad Reza Shiri-Shahsavar Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences, Qazvin, Iran. 0000-0002-6243-8361 Journal Article 2025 10 15 Background and Purpose: Type 2 diabetes is associated with hyperglycemia, insulin resistance, and oxidative stress. This study evaluated the separate and combined effects of high-intensity interval training (HIIT) and Burdock extract on metabolic and oxidative–antioxidant indices in a diabetic animal model.<br /><br />Methods: Fifty male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + Burdock, diabetic + HIIT, and diabetic + HIIT + Burdock. Blood glucose, insulin, insulin resistance (HOMA-IR), insulin sensitivity (QUICKI), MDA, GPx, and TAC were measured. Analysis was performed using one-way ANOVA followed by post hoc tests (Tukey/Welch), with a significance level set at p<0.05.<br /><br />Results: Compared to the diabetic group, each of the interventions (HIIT and Burdock alone) significantly reduced glucose and HOMA-IR, and increased insulin and TAC (p<0.05), while also significantly reducing MDA. The increase in GPx was significant in the Burdock and combined groups but not in the HIIT-only group (p<0.05). Only the combined HIIT + Burdock intervention significantly improved QUICKI (p<0.01), and it showed the greatest reduction in glucose and MDA, as well as the highest increase in insulin, GPx, and TAC (p≤0.001).<br /><br />Conclusions: Both HIIT and Burdock have beneficial effects on glucose control and the oxidative/antioxidant balance. However, their combined use shows an additive effect, outperforming the individual interventions. These findings support the development of multi-faceted approaches in managing type 2 diabetes. Background and Purpose: Type 2 diabetes is associated with hyperglycemia, insulin resistance, and oxidative stress. This study evaluated the separate and combined effects of high-intensity interval training (HIIT) and Burdock extract on metabolic and oxidative–antioxidant indices in a diabetic animal model.<br /><br />Methods: Fifty male Wistar rats were randomly divided into five groups: healthy control, diabetic control, diabetic + Burdock, diabetic + HIIT, and diabetic + HIIT + Burdock. Blood glucose, insulin, insulin resistance (HOMA-IR), insulin sensitivity (QUICKI), MDA, GPx, and TAC were measured. Analysis was performed using one-way ANOVA followed by post hoc tests (Tukey/Welch), with a significance level set at p<0.05.<br /><br />Results: Compared to the diabetic group, each of the interventions (HIIT and Burdock alone) significantly reduced glucose and HOMA-IR, and increased insulin and TAC (p<0.05), while also significantly reducing MDA. The increase in GPx was significant in the Burdock and combined groups but not in the HIIT-only group (p<0.05). Only the combined HIIT + Burdock intervention significantly improved QUICKI (p<0.01), and it showed the greatest reduction in glucose and MDA, as well as the highest increase in insulin, GPx, and TAC (p≤0.001).<br /><br />Conclusions: Both HIIT and Burdock have beneficial effects on glucose control and the oxidative/antioxidant balance. However, their combined use shows an additive effect, outperforming the individual interventions. These findings support the development of multi-faceted approaches in managing type 2 diabetes. https://jsb.ut.ac.ir/article_104872_3e8d1e27977a8a4c190db02c6011bbcc.pdf