TY - JOUR ID - 91172 TI - The Effect of 4 Weeks Aerobic Swimming Training and Aqueous Urtica Dioica Extract on PGC-1α and UCP-1 Gene Expression and Serum Concentrations of Irisin and FGF21 in Diabetic Rats JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - ranjbari, abas AU - Mohamadzadeh Salamat, Khalid AU - Akbarzadeh, Samad AU - Khamisipour, Gholamreza AU - Naeimi, Behrouz AD - Department of Physical Education and Sport Sciences, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran AD - . Corresponding Author Department of Physical Education and Sports Sciences, Faculty of Humanities, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran. AD - Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran. AD - Department of Laboratory Hematology and Blood Bank, Bushehr University of Medical Sciences, Bushehr, Iran. AD - Department of Medical Mycology, Bushehr University of Medical Sciences, Bushehr, Iran Y1 - 2022 PY - 2022 VL - 14 IS - 4 SP - 67 EP - 80 KW - Aerobic training KW - diabetes KW - Irisin KW - PGC-1α KW - UCP-1 KW - Urtica Dioica extract DO - 10.22059/jsb.2023.345715.1546 N2 - Introduction: Sports activity and Urtica Dioica extract consumption increase the expression of genes involved in the conversion of white to brown adipose tissue, but their combined effect is not yet clear. This study aimed to investigate the effect of Urtica dioica extract consumption and aerobic training on serum Irisin and FGF21 concentration and PGC-1α and UCP1 gene expression in diabetic obese rats. Methods: In an experimental design, Seventy male Wistar rats (mean weight: 227.35± 18.52 grams) were randomly divided into seven Healthy Control, Diabetic Control, Urtica Dioica, Metformin, Training, Urtica Dioica + Training, and Metformin + Training groups. The Training groups performed forced swimming training for four weeks, five days per week, and each day from 15 minutes (in the first week) to 50 minutes (in the fourth week). Each day, Urtica Dioica and Metformin groups received 1.25 and 100 mg/kg of these two substances, respectively via gavage. After the end of the intervention, rats’ blood samples, posterior thigh muscle tissues, pancreas, and fat (visceral) were taken to check the research variables. One-way analysis of variance and Bonferroni's post hoc test with a significance level of 0.05 was used to analyze the data. Results: The serum Irisin concentration of the Metformin + exercise group was significantly higher than the Diabetic Control group (P<0.05). No significant difference was observed in the serum FGF21 concentration of all groups. A significant increase in PGC-1α and UCP-1 gene expression was observed in all treatment groups compared to Healthy Control and Diabetic Control groups (P<0.05). Conclusion: The simultaneous consumption of Urtica Dioica extract and swimming training reduces blood glucose and also activates the PGC-1α and UCP-1 gene expression, which play a role in adipose tissue browning. UR - https://jsb.ut.ac.ir/article_91172.html L1 - https://jsb.ut.ac.ir/article_91172_7ee480744f1e827250b35e768a774f6e.pdf ER -