TY - JOUR ID - 82117 TI - The Effect of High Intensity Interval Training and Continuous Endurance Training on Gene Expression of mir-1 and IGF-1 in Cardiomyocyte of Diabetic Male Rats JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - Delfan, Maryam AU - Kordi, Mohammad Reza AU - Ravasi, Ali Asghar AU - Safa, Majid AU - Nasli Esfahani, Ensieh AU - Rambod, Kamelia AD - Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran AD - Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran AD - Associate Professor of Cellular and Molecular Research Center, Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran AD - Research Associate Professor of Endocrinology and Metabolism, Diabetes Research Center, Endocrinology and Metabolism Research Center, University of Medical Sciences, Tehran, Iran AD - Researcher of Endocrinology and Metabolism, Endocrinology and Metabolism Research Center, University of Medical Sciences, Tehran, Iran Y1 - 2021 PY - 2021 VL - 13 IS - 1 SP - 11 EP - 23 KW - Cardiomyopathy KW - IGF-1 KW - microRNA-1 KW - Training DO - 10.22059/jsb.2021.118369.892 N2 - This study aimed to compare high intensity interval training and continuous endurance training on the gene expression of mir-1 and IGF-1 in cardiomyocytes of diabetic rats. After induction of diabetes, 21 male Wistar rats were randomly divided into three groups (each group 7 subjects): control, continuous endurance training, high intensity interval training). The training program included 5 days a week for 8 weeks. Each endurance session consisted of 30 minutes of running with the intensity of 60% VO2max. Each interval session consisted of 4 intervals, each interval 3 minutes, with the intensity of 90% VO2max and 1 minute of recovery with the intensity of 30% VO2max between each two intervals. Gene expression of IGF-1 and mir-1 of left ventricle tissue was assessed by qRT PCR. The results showed that both types of training significantly reduced the gene expression of mir-1 compared to the control group, but this decline was severer in the high intensity interval group than the endurance group (P≥0.05). Also, the gene expression of IGF-1 significantly increased in both training groups compared to the control group but this increase was severer in high intensity interval group than the endurance group (P≥0.05). It seems that high intensity interval training can be an effective intervention to reduce the complications of diabetic cardiomyopathy by repression of mir-1. UR - https://jsb.ut.ac.ir/article_82117.html L1 - https://jsb.ut.ac.ir/article_82117_51ad50ed66a02f534fe4ec2f85695836.pdf ER -