TY - JOUR ID - 81036 TI - The Effects of HIIT and Curcumin Supplementation on CD31+ Capillary Cell Count and the Expression of VEGF and MMP9 of Left Ventricle in Isoproterenol Induced Myocardial Infraction Model Rats JO - Journal of Sport Biosciences JA - JSB LA - en SN - 2008-9325 AU - Alabaf Yousefi, Farideh AU - Pouzesh Jadidi, Roghayeh AU - Bashiri, Jabbar AU - Azali Alamdari, Karim AU - Vakili, Javad AD - PhD Student of Exercise Physiology, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran AD - Assistant Professor, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran AD - Associate Professor of Exercise Physiology, Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran AD - . Associate Professor, Department of Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran AD - Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz University, Tabriz, Iran Y1 - 2021 PY - 2021 VL - 13 IS - 2 SP - 179 EP - 194 KW - angiogenesis KW - Curcumin KW - high intensity interval training KW - infraction DO - 10.22059/jsb.2021.314284.1448 N2 - The effects of high intensity interval training (HIIT) and curcumin supplementation on CD31+ capillary cell count and the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP9) in left ventricle (LV) of male rats in the model of myocardial infraction were determined in this study. 40 male rats were divided into four groups: HIIT, curcumin, concomitant (HIIT+CUR) and control following isoproterenol induced myocardial infarction. Curcumin was administered through oral gavage as 15 mg/kgbw/day. HIIT was performed for 8 weeks, 5 sessions a week and included 60 minutes of interval running (4 min. of running with the intensity of 85-90% of VO2max and 2 min. of active recovery with the intensity of 50-60%). The results showed that HIIT in both HIIT and concomitant groups significantly increased LV VEGF protein expression (P=0.001) while no effect was noted for curcumin (P>0.05). Only curcumin significantly reduced (P=0.001) LV MMP9 protein expression (in both curcumin and concomitant groups). All three interventions significantly increased LV CD31+ capillary cell count (P=0.001). A significantly greater effect was noted for HIIT than curcumin (P=0.001) and for concomitant than both HIIT and curcumin (P=0.001). The results showed that all three interventions including curcumin, HIIT and concomitant were involved in capillary proliferation following infraction; however, curcumin induced capillary growth seems to occur through paths independent of VEGF as well. But the exact function of MMP9 down-regulation induced by curcumin is still unclear and more research is required because of the study limitations.  UR - https://jsb.ut.ac.ir/article_81036.html L1 - https://jsb.ut.ac.ir/article_81036_f09a6bc044dc0b2e8c627a4bd9f9c320.pdf ER -