University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Effect of 4 Weeks High Intensity Interval Training on Gene Expression of Ryanodine Receptor Calcium Channels (RyR2), SERCA2a and Phospholamban in dDiabetic Rat’s Heart
1
12
FA
Mohammad Reza
Izadi
. Ph.D. Student of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
izadi.mreza@gmail.com
Abbas Ali
Gaeini
0000-0002-8679-0669
Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
aagaeini@ut.ac.ir
Ali Asghar
Ravasi
professor Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran,Iran.
aa.ravasi@ut.ac.ir
Maryam
Delfan
Assistant Professor, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran
m.delfan@ut.ac.ir
10.22059/jsb.2018.122543.915
Diabetic cardiomyopathy (DCM) is one of the most important complications of diabetes and is one of the major causes of death in diabetic patients. DCM at the molecular level is rooted in down regulation of expression or activity of those various proteins involved in maintenance or regulation of intracellular calcium homeostasis. The aim of this study was to investigate the effect of 4 weeks of high intensity interval training (HIIT) on gene expression of calcium channel of ryanodine receptors (RyR2), SERCA2a and phospholamban (PLB) in the heart of diabetic male rats. In this experimental study, 24 male Wistar rats were divided into two groups: sedentary control and HIIT. Diabetes was induced in both groups by intraperitoneal injection of Streptozotocin (STZ) solution. 24 hours after the last training session, the rats were euthanized and their left ventricle was extracted. Real Time-PCR technique was used to determine the gene expression of RyR2, SERCA2a and PLB. To compare the two groups, independent t test was used at alpha level of 0.05. The results revealed that 4 weeks of HIIT significantly increased gene expression of RyR2 in the left ventricle of the heart of HIIT group (<em>P</em>=0.03). Although gene expression of SERCA2a and phospholamban increased, they were not significantly different. Based on these findings, it can be concluded that 4 weeks of HIIT could prevent and minimize the maladjustments in these 2 proteins affecting cycle of cardiac contraction and reduce the risk of diabetic cardiomyopathy through increased RyR2 gene expression in the heart of diabetic rats.
Diabetic cardiomyopathy,RyR2,SERCA2a,PLB
https://jsb.ut.ac.ir/article_66970.html
https://jsb.ut.ac.ir/article_66970_3af3a3f424415b00b06bbf9c6f32683a.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Vascular Endothelial Growth Factor Receptor-2 and the Plmonary Vascular Volume Tracking, after 6 Weeks of High-Intensity Interval Training
13
24
FA
Shadmehr
Mirdar
0000-0003-3075-1529
Professor, PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
shadmehr.mirdar@gmail.com
Gholamreza
Hamidiyan
0000-0002-8200-7243
Assistant Professor, PhD of Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
ghamidian@yahoo.com
Mehdi
Yadegari
. PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran
mehdi.sport313@yahoo.com
10.22059/jsb.2018.200362.1044
VEGF-2 has most potent angiogenic signaling associated with VEGF that So far,no has been published research in relation to the effect of exercise training on the vascular volume and it, in the lung . therefore, present study aim was investigate the effect of an high-intensity interval training period on VEGFR-2 expression and pulmonary vascular volume in male Wistar rats. This research including the experimental studies that samples its had formed 10 male Wistar rats,that to form of Randomly and equally were divided into training and control groups. Training program Was started with 25 meters per minute and with 70 meters per minute was Finished at the end of the period. In each training session, rats completed the 1-min activity with 10 repetition and work to rest ratio was 1:2. In the end, lung tissue extracted for stereologicaly and Immunohistochemistry tests. Statistical analysis whit Independent t-test, and Pearson correlation coefficient showed, significantly increase in VEGFR-2(sig: 0/001) and pulmonary vascular volume(sig: 0/042) in the exercise group compared to the control group, and positive correlation between changes in these two indicators whit exercise(sig: 0/035). In general it seems that 6 weeks of high-intensity interval training has potential to promote of lung angiogenic processes.
high intensity interval training,Lung,Vascular andothelial growth factor,Vascular volume
https://jsb.ut.ac.ir/article_66989.html
https://jsb.ut.ac.ir/article_66989_b109a4f049a34d73bb800e4df3a1c446.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
The Effect of High Intensity Interval Training on the Expression of the Muscle Myonectin Llevels and Insulin rResistance Index in Adult Male Wistar Rats
25
38
FA
Hamed
Barzegar
PhD of Exercise Physiology, University of Tehran, Tehran, Iran
h.barzegar@ut.ac.ir
Rahman
Soori
Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
rahmansoori@yahoo.com
Ali
Akbarnezhad
0000-0003-0154-351X
Assistant Professor, Department of Anatomy, Faculty of Medical Sciences, University of Tarbiat Modares, Tehran, Iran
aakbarnejad@ut.ac.ir
Zohre
Mazaheri
Assistant Professor, Faculty of Physical Education and Sport Sciences, University of Shahrood, Shahrood, Iran
mazaheri2020@yahoo.com
Fatemeh
Shabkhiz
0000-0003-1183-9517
Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
shabkhiz@ut.ac.ir
10.22059/jsb.2018.220341.1125
The aim of this study was to investigate the effect of four weeks of high intensity interval training on muscle myonectin gene expression and insulin resistance index, in the male adult rats. Fourteen Wistar rats (age: eight weeks) were divided into two groups: (1) interval training and (2) control groups. Animals in exercise groups received 4-wk interval training (five sessions per week) that included running on a treadmill and at the same time, the control group did not have any training. The soleus muscle homogenates and the expression of myonectin genes were measured by Real-time PCR analysis. The ELISA method for measuring insulin resistance index. The data were analyzed by Independent t-test. Statistical differences were considered significant at P
high intensity interval training,insulin resistance,Metabolism,Myonectin
https://jsb.ut.ac.ir/article_66990.html
https://jsb.ut.ac.ir/article_66990_92216f0623d13414ff4481d7b111a7e9.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
The Effect of 14 Weeks Aerobic Exercise on Resveratrol Supplementation on Protein UCP-1, SIRT1, PGC-1α in Liver Tissue, Subcutaneous and Visceral Fat Tissue in Male Wistar Rats
39
58
FA
Hadi
Zahedi
.PhD Student of Sport Biochemistry and Metabolism, Islamic Azad University, Central Tehran Branch
h.zahedi2@gmail.com
Maqsood
Piriee
گروه فیزیوبوژی، دانشکده تربیت بدنی دانشگاه آزاد تهران مرکزی
m.peeri@iauctb.ac.ir
mehdi
hedayati
Associate Professor of Endocrinology and Metabolism Research Institute, Shahid Beheshti University of Medical Sciences, Tehran
hedayati47@yahoo.com
10.22059/jsb.2018.227987.1151
The purpose of this study was to determine the effects of resveratrol supplementation and Aerobic training on protein levels of SIRT-1, PGC-1α and UCP-1 liver tissue and abdominal & inguinal subcutaneous adipose tissue in adult male Wistar rats. In this study, 28 male rat (w=260+10gr, 8 weeks) divided into 4 (n=8) groups: control (C), aerobic training (T), complement-training (T-R) and supplements (S) randomly. Training groups exercised for 14 weeks (5 sessions a week, each session 45 minutes on a treadmill. ELISA (sandwich double) was used to measure tissue proteins UCP-1, SIRT1, PGC-1α. ANOVA test used for data analysis and statistical significance (p≤0.05) were considered. SIRT1 and PGC-1α protein was observed changes in liver tissue and subcutaneous / visceral white adipose tissue, respectively (P≤0.05) and (P≤0.001). Increased protein UCP-1 is also measured in tissues-workout supplement after supplement in combination with aerobic activity (P≤0.001). According to our results, are likely to impact more powerful, resveratrol supplementation with aerobic physical activity increases the amount of UCP-1, SIRT1, PGC-1α tissue to separate than from physical activity or resveratrol supplements, And is likely to Improved liver function and change subcutaneous white adipose tissue to beige or intermediate phenotype.
UCP-1,SIRT1,PGC-1α,Aerobic training,Resveratrol
https://jsb.ut.ac.ir/article_66996.html
https://jsb.ut.ac.ir/article_66996_9365749661ea2491f8f86fdd8f9c5d2f.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2020
02
18
A Comparison of Sympathetic Neural and Endothelial Vasoreactivity of Brachial Artery in Elite Weightlifters with a Sedentary Age-Matched Control Group
59
75
FA
Mahdi
Khorshidi-Hosseini
Assistant Professor, Department of physical education and sport sciences, Faculty of Humanities, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
mahdi.khorshid55@gmail.com
Lotfali
Boboli
Associated Professor, Department of physical education and sport sciences, Faculty of education sciences and psychology, University of Mohaghegh Ardabili, Ardabil, Iran
sbolboli@yahoo.com
Salim
Vahedi
Assistant Professor, Department of physical education and sport sciences, Faculty of education sciences and psychology, University of Mohaghegh Ardabili, Ardabil, Iran
vahedis@uma.ac.ir
10.22059/jsb.2018.240341.1202
The aim of the present study was to compare the sympathetic neural and<br />endothelial responses of brachial artery to vasodilatory and constrictor<br />stimuli in elite weightlifters and a sedentary age-matched control group. 7<br />elite weightlifters (age 23.5±2.2 yrs) and 8 sedentary healthy subjects (age<br />24.3±2.12 yrs) voluntarily participated in this study. High-resolution<br />Doppler ultrasound was used to determine brachial artery diameters at rest,<br />following 5 minutes of forearm occlusion [Flow Mediated Dilation (FMD)]<br />and during acute sympathetic stimulation [cold pressure test (CPT)].<br />Vasoreactivity responses were calculated from the vasodilatory and<br />constrictor peak changes in artery diameter. The acquired data were analyzed<br />using independent t test and repeated measures method at P≤0.05. Brachial<br />artery diameters in baseline [mean differences, 0.5 mm (P=0.001)], peak<br />vasodilation [mean differences, 0.57 mm (P=0.002)] and peak constriction<br />[mean differences, 0.498 mm (P=0.003)] were significantly greater in<br />weightlifters than control group. However, no significant difference was<br />observed in %FMD, %CPT and vascular operating range (VOR) between<br />weightlifters and age-matched control group (P≤0.05). The present study<br />indicated that the function of brachial artery is not necessarily enhanced in<br />elite weightlifters. However, elite weightlifters had larger brachial artery<br />diameter than age-matched healthy control subjects.
Brachial artery,elite weightlifters,endothelial function,vasoreactivity
https://jsb.ut.ac.ir/article_75050.html
https://jsb.ut.ac.ir/article_75050_47da267543a5e7f0bcfbb7c3d8612b36.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Adjuvant Effect of Short Term Endurance Training on Regulatory T Cells in HSV-1 Vaccine and Its Boosters
77
85
FA
Mahdiyeh
Molanouri
. Assistant Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
molanouri@modares.ac.ir
Afsaneh Jamali
Jamali
MSc Student of Exercise Physiology, Tarbiat Modares University, Tehran, Iran y
jamali.afsaneh@gmail.com
Mehdi
Mahdavi
Assistant Professor, Medical Immunology Department, Pasteur Institute of Iran, Tehran, Iran
mahdavivac@gmail.com
10.22059/jsb.2018.214217.1104
Introduction: The herpes simplex viruses (HSV) cause a variety of clinical illnesses that are painful and often distressing. To control the infection, the development of an effective vaccine that prevents or reduces the primary and recurrent infections would be of great significance. Chronic and acute exercise training were used as a vaccine adjuvant in some studies. The purpose of this study was to assess adjuvant effects of short term endurance exercise training on regulatory T cells in HSV-1 vaccine model. Methods & Materials: 24 BALB/C mice were divide into 3 groups: control, vaccine and vaccine plus short term endurance exercise training. TGF-β levels as index of reglulatory T cells activation were determined in spleen cell culture with ELISA method. One-way ANOVA were used for statistical analysis. Results: The result of this study indicated that there are significant differences between group in reglulatory T cells activation (P<0.05). Tukey post-hoc test results showed significant differences between control and vaccine groups with vaccine plus short term endurance exercise training group (P<0.05). Conclusion: Results of current study showed that reglulatory T cells activation increased following using short term endurance exercise training as an adjuvant. These results suggested that coupling short term moderate exercise training with vaccination may enhance vaccine efficacy. Further studies are in order to determine effects of different kind of exercise as an adjuvant in different types of vaccine can be considerate.
Adjuvant,Endurance training,Herpes Simplex viruses,Regulatory T Cells
https://jsb.ut.ac.ir/article_67024.html
https://jsb.ut.ac.ir/article_67024_9f6957c761c8e3c6736f1ae7fe7c43db.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
29
The Effect of Vitamin D Consumption during Progressive Resistance Training on Malondialdehyde and Creatine Kinase Changes in Untrained Men
87
101
FA
Fardin
Kalvandi
. Assistant Professor of Exercise Physiology, Department of Physical Education, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
fardin.vm@gmail.com
Kamal
Aziz bagi
. Assistant Professor of Exercise Physiology, Department of Physical Education, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
Mohamad ali
Azarbayjani
0000-0002-7316-0369
. Professor of Exercise Physiology, Department of Exercise Physiology, Tehran Central Branch, Islamic Azad University, Tehran, Iran
ali.azarbayjani@gmail.com
Mohammad
Abdi
Assistant Professor of Biochemistry, Kurdistan University of Medical Sciences, Sanandaj, Iran
abdi@muk.ac.ir
10.22059/jsb.2018.67030
Resistance exercises increase oxidative stress and muscle damage. The aim of the present study was to investigate the effect of vitamin D on MDA and CK changes during 8 weeks of progressive resistance training. 40 male subjects (age range 20-25 years) participated in the study voluntarily and were randomly assigned to 4 groups: vitamin D-resistance training (RTD; n=10), placebo-resistance training (RTP; n=10), vitamin D (VD; n=10) and control (con; n=10). Progressive resistance training was performed 3 sessions a week, every other day for 8 weeks with eight movements and increased intensity. Subjects in RTD and VD groups consumed a 50000-IU capsule of vitamin D every two weeks. Blood samples were gathered before and after the training period. Plasma was used to assess CK activity and MDA concentration. Results showed no significant difference among the groups in CK (P˃0.05). However, it was observed that MDA changes in group x time interaction was significant (P=0.001), that is to say MDA concentration significantly decreased in RTD group compared with VD (P=0.017) and control (P=0.034) groups. Also, MDA concentration was significantly lower in RTP than VD in the posttest (P=0.045). However, there was no significant difference between RTD and RTP. Finally, it can be said that the combination of resistance training and vitamin D can decrease lipid peroxidation. However, it seems that resistance training role is very important in this regard.
Antioxidant supplement,cell damage,Lipid Peroxidation,resistance training
https://jsb.ut.ac.ir/article_67030.html
https://jsb.ut.ac.ir/article_67030_2230b2a1fc98b3a0e3b93cc9fa4661dd.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Effect of Unsaturated-High-Fat-Diet and Aerobic Training Program on Serum levels of Adiponectin Isoforms, Insulin Resistance and Lipid Profile in Male obese Rats
103
118
FA
Payam
Saidie
0000-0001-7325-9484
. Assistant Professor, Guilan University, Rasht, Iran
payam.saidie@gmail.com
Hamid
Mohebbi
0000-0003-1524-9530
. Professor, Guilan University, Rasht, Iran
mohebbi_h@yahoo.com
Farhad
Rahmani nia
0000-0002-7021-0065
. Professor, Guilan University, Rasht, Iran
frahmani2001@yahoo.com
Fahime
Mohammad Ghasemi
Histology Department, Medical science University, Guilan university, Rasht, Iran
parsahistolab@gmail.com
10.22059/jsb.2018.250623.1238
The aim of present study was to investigate the effect of 10-week aerobic training and unsaturated-high-fat-diet on adiponectin serum in obese male rats. Blood samples were collected of forty-eight wistar male rats (average weight 195±5g, age 8 weeks) at 1st, 18th and 28th weeks after overnight fasting. After first sampling, remaining 40 rats were randomly divided into control (n=16) and high-fat-diet (39% of energy content from unsaturated-fat) (n=24). High-fat-diet group randomly divided in to exercise training and high-fat-diet subgroups after 18 weeks. Exercise training group ran for 10 weeks (5d/wk) with intensity equivalent to 70 to 75% of vo2max. Serum levels of total and HMW adiponectin as well as lipid profile and glycemic variables were measured. The results of this study indicate that in comparison to unsaturated-high-fat-diet, aerobic training in unsaturated-high-fat-diet induced obese male rats, increased serum concentration of total adiponectin significantly (P> 0/01). Also insulin resistance index and serum concentrations of insulin, glucose, total cholesterol, LDL-C and TG were decreased in aerobic exercise compare to high-fat-diet group (P> 0/05). This study indicates that aerobic training increase serum concentrations of total adiponectin in obese male rats even with simultaneous consumption of unsaturated-high-fat-diet and cause improvement in lipid and metabolic profiles.
Adiponectin,insulin resistance,Aerobic training,Unsaturated-high-fat-diet,lipid profile
https://jsb.ut.ac.ir/article_67026.html
https://jsb.ut.ac.ir/article_67026_6fa12f19b5296f4524fbf4d5a17f80bf.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Responses of Serum Levels of Neurotrophic factors to Carbohydrate Consumption during Aerobic Exercise Training in Adolescent Men’s Futsal Players
119
131
FA
Rasoul
Eslami
Assistant Professor, Faculty of Sport Sciences, Allameh Tabataba’i University, Tehran, Iran
valipour.v@lu.ac.ir
Vahid
Valipour Dehnou
Associate Professor, Sport Sciences Department, Literature and Human Sciences Faculty, Lorestan University, Khorramabad, Iran
valipour114@yahoo.com
Heshmatollah
Alikarami
. MSc of Exercise Physiology, Physical Education Faculty, Shahid Chamran University, Ahwaz, Iran
vahidvalipourdehnou@gmail.com
10.22059/jsb.2018.245431.1217
Neurotrophic factors mediate the effects of physical activity on brain health and function. The aim of study was to study the effect of aerobic exercise in the form of treadmill running with and without carbohydrate supplementation on serum levels of BDNF, NT-3, NT-4 and IGF-1. In this semi-experimental study, 12beginner adolescent men’s futsal players in Khorramabad city (age: 17.13±0.64years; weight: 64.25±10.18kg; height: 172.88±5.59cm) voluntarily selected. Subjects performed 1hour of treadmill running with moderate intensity (60% heart rate reserve) in two sessions with carbohydrate supplementation and placebo, in a randomized cross-over design. Blood samples were obtained before first training session and 5min after training sessions. The serum BDNF, NT-3, NT-4 and IGF-1 concentrations were measured using an ELISA kit. Statistical analysis were performed by repeated measures test and the level of significance was set at p0.05). Also, there was no change in serum levels of IGF-1 (p =.099). One hour of aerobic exercise with moderate intensity with and without carbohydrate supplementation equally leads to increase serum levels of BDNF, NT-3 and NT-4. Therefore, it seems that in order to increase the effects of carbohydrate supplementation on serum levels of neurotrophins, duration/intensity of exercise, or both, or concentration of carbohydrate should be increased.
Aerobic training,Carbohydrate,Futsal,Neurotrophic factors
https://jsb.ut.ac.ir/article_67027.html
https://jsb.ut.ac.ir/article_67027_769af4467af3e33e7e0c5ca8cf8686d3.pdf
University of Tehran
Journal of Sport Biosciences
2008-9325
2676-4148
10
1
2018
05
22
Effect of High Intensity Aerobic Exercise Training and Arginine supplementation on Hormonal Changes in Leptin and Agouti-Related Protein (AGRP) in Obese Adolescent Boys
133
148
FA
Tohid
Mabhout Moghadam
Ph.D. Student of Biochemistry and Sport Metabolism, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran
tohid.moghadam@gmail.com
Mehrdad
Fathei
Associate Professor-Ferdowsi University of Mashhad
dr.mfathei@gmail.com
Reza
Attarzadeh
assisstant professor
rattarzadeh@yahoo.com
Amir
Rashid lamir
0000-0001-6180-8554
Associate Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran
amir.rashidlamir@gmail.com
Mohamad
Mosaferi
Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran
mosaferi@um.ac.ir
10.22059/jsb.2018.251573.1244
Abstract<br />There is low information about the effects of high intensity aerobic exercise training (HIT) and the use of supplementation of arginine on appetite regulating hormones, along with nutritional control in obese adolescents. The purpose of this study was to determine the effect of eight weeks of HIT and supplementation of arginine on hormonal changes in leptin and agouti-related protein (AGRP) in obese adolescent boys. In isoenergetic conditions, 20 obese adolescents were according to aerobic power divided into two groups including: 1) HIT and placebo (C, n=10) and HIT with supplementation of arginine (T, n=10).Before Intervention exercise Protocol and 48 hours after the last exercise session, levels of appetite regulating hormones were measured in blood. For Investigation the differences between intra-and intergroup, Independent and independent Student was used. The results intra-and intergroup showed that there was no significant difference between leptin, AGRP compared to baseline levels among and between in C and T groups (P ≥0.05). Conclusion: Both exercise and supplement- exercises have different effects on the regulation of appetite in obese adolescent boys. However, the results of these works may not be palpable in some indices.
"High Intensity Aerobic Exercise Training","Obesity","Arginine","Leptin","Agouti-related protein"
https://jsb.ut.ac.ir/article_67028.html
https://jsb.ut.ac.ir/article_67028_469fd74e5627cf844dc6b3723169a1fd.pdf