ORIGINAL_ARTICLE
The Acute Effects of High Intensity Interval Training (HIIIT) on PGC-1α and FNDC5 Genes Expression in Diabetic Rats
Change in adipose tissue phenotype caused by exercise training is new theory that as result of muscle FNDC5 gene expression. The aim of the present study is to investigate the acute effects of high intensity interval training (HIIT( on PGC-1α and FNDC5 genes expression of diabetic rats. In this study, 18 diabetic wistar rats(12 week- age, 220-240 gr- weight) were assigned to three groups: high intensity interval training Immediately (HIIE0)(n=6), high intensity interval training 2hours later (HIIE2)(n=6) and control(C)(n=5). Both HIIT groups activated on the treadmill with 90-95% vo2max in the 12 interval-one minute period and 1 minute rest intervals. Real time PCR method was used for the relative expression of mRNA FNDC5 and PGC-1α. One-way ANOVA and Tukey Post hoc test has used to data analysis, the level of significance has been consider at 0/05. Data Analysis showed significant differences Research groups in expression of mRNA FNDC5 and PGC-1α (p≤0/01.) Tukey test showed, FNDC5 and PGC-1α gene expression In the 2 groups high intensity interval training(HIIT0-HIIT2) compared to the control group significantly increased (p≤0/01).
https://jsb.ut.ac.ir/article_79514_2178143bd106baca7811f4364aadbd2a.pdf
2020-11-21
249
261
10.22059/jsb.2020.119643.902
high intensity interval training (HIIIT)
FNDC5 gene expression
PGC-1α gene expression
diabetic rats
Mousa
Khalafi
mousa.khalafi@ut.ac.ir
1
PhD of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran
LEAD_AUTHOR
Ali Asghar
Ravasi
aaravasi@ut.ac.ir
2
Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran,
AUTHOR
Rahman
Soori
soorirahman@yahoo.com
3
Professor, Department of Exercise Physiology, Faculty of Physical Education, University of Tehran, Tehran, Iran
AUTHOR
Mohammad
Moradi
m.moradi13@ut.ac.ir
4
PhD Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
AUTHOR
Massoud
Soleimani
m69_15@yahoo.com
5
Associate Professor, Tarbiat Modares University, Tehran, Iran
AUTHOR
1. Gulcelik, N.E., A. Usman, and A. Gürlek, Role of adipocytokines in predicting the development of diabetes and its late complications. Endocrine, 2009. 36(3): p. 397-403.
1
2. Eckardt, K., et al., Myokines in insulin resistance and type 2 diabetes. Diabetologia, 2014. 57(6): p. 1087-1099.
2
3. Raschke, S. and J. Eckel, Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators of inflammation, 2013. 2013.
3
4. Boström, P., et al., A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 2012. 481(7382): p. 463-468.
4
5. Handschin, C. and B.M. Spiegelman, The role of exercise and PGC1α in inflammation and chronic disease. Nature, 2008. 454(7203): p. 463-469.
5
6. van Marken Lichtenbelt, W.D., et al., Cold-activated brown adipose tissue in healthy men. New England Journal of Medicine, 2009. 360(15): p. 1500-1508.
6
7. Pekkala, S., et al., Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? The Journal of physiology, 2013. 591(21): p. 5393-5400.
7
8. Mahajan, R.D. and S.K. Patra, Irisin, a novel myokine responsible for exercise induced browning of white adipose tissue. Indian Journal of Clinical Biochemistry, 2013. 28(1): p. 102.
8
9. Choi, Y.-K., et al., Serum irisin levels in new-onset type 2 diabetes. Diabetes research and clinical practice, 2013. 100(1): p. 96-101.
9
10. Moholdt, T.T., et al., Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life. American heart journal, 2009. 158(6): p. 1031-1037.
10
11. Laursen, P.B. and D.G. Jenkins, The scientific basis for high-intensity interval training. Sports medicine, 2002. 32(1): p. 53-73.
11
12. Gibala, M.J., et al., Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology, 2012. 590(5): p. 1077-1084.
12
13. Burgomaster, K.A., et al., Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. The Journal of physiology, 2008. 586(1): p. 151-160.
13
14. Gibala, M.J. and S.L. McGee, Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? Exercise and sport sciences reviews, 2008. 36(2): p. 58-63.
14
15. Helgerud, J., et al., Aerobic high-intensity intervals improve V˙ O2max more than moderate training. Medicine & Science in Sports & Exercise, 2007. 39(4): p. 665-671.
15
16. Perry, C.G., et al., High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism, 2008. 33(6): p. 1112-1123.
16
17. Boutcher, S.H., High-intensity intermittent exercise and fat loss. Journal of obesity, 2011. 2011.
17
18. Gibala, M.J., et al., Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle. Journal of applied physiology, 2009. 106(3): p. 929-934.
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19. Khalafi, M., et al., The impact of moderate-intensity continuous or high-intensity interval training on adipogenesis and browning of subcutaneous adipose tissue in obese male rats. Nutrients, 2020. 12(4): p. 925.
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20. Khalafi, M., H. Mohebbi, and P. Karimi, High-intensity interval training increases mitochondria biogenesis in adipose tissue and improves insulin resistance in high fat diet-induced obese rat. International Journal of Applied Exercise Physiology, 2019. 8(1): p. 43-50.
20
21. Soyal, S., et al., PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes. Diabetologia, 2006. 49(7): p. 1477-1488.
21
22. Liang, H. and W.F. Ward, PGC-1α: a key regulator of energy metabolism. Advances in physiology education, 2006.
22
23. Calcutt, N.A., Modeling diabetic sensory neuropathy in rats, in Pain Research. 2004, Springer. p. 55-65.
23
24. Høydal, M.A., et al., Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. European Journal of Cardiovascular Prevention & Rehabilitation, 2007. 14(6): p. 753-760.
24
25. Huh, J.Y., et al., FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 2012. 61(12): p. 1725-1738.
25
26. Shaban, N., K. Kenno, and K. Milne, The effects of a 2 week modified high intensity interval training program on the homeostatic model of insulin resistance (HOMA-IR) in adults with type 2 diabetes. The Journal of sports medicine and physical fitness, 2014. 54(2): p. 203-209.
26
27. Wenz, T., et al., Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences, 2009. 106(48): p. 20405-20410.
27
28. Wende, A.R., et al., A role for the transcriptional coactivator PGC-1α in muscle refueling. Journal of Biological Chemistry, 2007. 282(50): p. 36642-36651.
28
29. Lin, J., et al., Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice. Cell, 2004. 119(1): p. 121-135.
29
30. Little, J.P., et al., An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011. 300(6): p. R1303-R1310.
30
31. Raschke, S. and J. Eckel, Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise. Mediators of Inflammation, 2013. 2013: p. 320724.
31
32. Tjønna, A.E., et al., Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome. Circulation, 2008. 118(4): p. 346-354.
32
33. Pekkala, S., et al., Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol, 2013. 591(21): p. 5393-400.
33
34. Huh, J.Y., et al., FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 2012. 61(12): p. 1725-38.
34
35. Chen, Z.-P., et al., AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. American Journal of Physiology-Endocrinology and Metabolism, 2000. 279(5): p. E1202-E1206.
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36. Jäger, S., et al., AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences, 2007. 104(29): p. 12017-12022.
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37. Knutti, D., D. Kressler, and A. Kralli, Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proceedings of the National Academy of Sciences, 2001. 98(17): p. 9713-9718.
37
38. Huh, J.Y., et al., Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation. The Journal of Clinical Endocrinology & Metabolism, 2014. 99(11): p. E2154-E2161.
38
39. Tsuchiya, Y., et al., High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. The Tohoku journal of experimental medicine, 2014. 233(2): p. 135-140.
39
ORIGINAL_ARTICLE
A Comparison of the Strength, Range of Motion and Balance in Active and Inactive Groups with Multiple Sclerosis
Multiple sclerosis affects normal life of the patients as it affects their motor performance. This study aimed to investigate strength, range of motion and balance in multiple sclerosis patients in the active and inactive groups. In this cross-sectional, ex-post facto study, 72 patients with MS and 38 healthy subjects as the control group from Mazandaran province participated voluntarily in this study. They were divided into four groups: active control (n=18), inactive control (n=20), active MS (n=27) and inactive MS (n=45). The maximum strength of quadriceps, trunk extensors, range of motion of quadriceps, hamstring, gastrocnemius and soleus muscles in both legs and balance were assessed through static and dynamic plantar pressure MAT tests. All findings were analyzed by one-way ANOVA test. The results showed significant differences in maximal strength (P=0.008), strength of the trunk extensors (P=0.001), static balance (P=0.006), COP changes with open eyes (P=0.001), and closed eyes (P=0.001) between the active and inactive groups. Contrary to the perception of those involved in MS (i.e. physical activity does not affect their functional or physiological symptoms), the results showed that given the difference between active and inactive subjects, it seems that physical activity in these patients minimizes those symptoms associated with the disease, especially in balance and strength.
https://jsb.ut.ac.ir/article_79515_c6b8adee4b098b0473835928abf714b2.pdf
2020-11-21
263
276
10.22059/jsb.2019.285313.1351
balance
center of pressure
Multiple Sclerosis
range of motion
strength
Vahid
Talebi
v.talebi@umz.ac.ir
1
Department of sport physiology and Biomechanics. Faculty of sport Sciences. University of Mazandaran. Babolsar. Iran
AUTHOR
Ziya
Fallahmohammadi
zia-falm@umz.ac.ir
2
Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
LEAD_AUTHOR
Payam
Saadat
sepanta1968@yahoo.com
3
Department of Neurology, Mobility impairment Research Center, Health Research Institue, Babol University of Medical Sciences, Babol,Iran
AUTHOR
Sayed Esmaeil
Hosseini Nejad
esmaeilhoseninejad@gmail.com
4
Department of Sport Biomechanics and Motor Behavior, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
AUTHOR
1. Stedman TL. Stedman's medical dictionary for the health professions and nursing: Lippincott Williams & Wilkins; 2005.
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2. Kent-Braun J, Ng A, Castro M, Weiner M, Gelinas D, Dudley G, et al. Strength, skeletal muscle composition, and enzyme activity in multiple sclerosis. J APPL PHYSIOL. 1997;83(6):1998-2004.
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3. Ingram D, Thompson A, Swash M. Central motor conduction in multiple sclerosis: evaluation of abnormalities revealed by transcutaneous magnetic stimulation of the brain. J Neurol Neurosurg Psychiatry. 1988;51(4):487-94.
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5. McDonald I, Compston A. The symptoms and signs of multiple sclerosis. McAlpine's multiple sclerosis. 2006; 4:327-33.
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7. Howard J, Trevick S, Younger DS. Epidemiology of multiple sclerosis. NEUROL CLIN . 2016;34(4):919-39.
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9. Kamalian Lari S, Haghgoo HA, Farzad M, Hosseinzadeh S. Investigation of the Validity and Reliability of Balance Evaluation Systems Test (BESTest) in Assessment of Balance Disorders in People with Multiple Sclerosis. Arch Phys Med Rehabil . 2018;18(4):288-95.
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13. Krishnan V, Kanekar N, Aruin AS. Anticipatory postural adjustments in individuals with multiple sclerosis. Neurosci. Lett. 2012;506(2):256-60.
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15. Varalta V, Fonte C, Munari D. The Influence of Cognitive Factors on Balance and Gait. Advanced Technologies for the Rehabilitation of Gait and Balance Disorders: Springer; 2018. p. 121-34.
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16. Karst GM, Venema DM, Roehrs TG, Tyler AE. Center of pressure measures during standing tasks in minimally impaired persons with multiple sclerosis. J Neurol Phys Ther. 2005;29(4):170-80.
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21. Yang Y-R, Lee Y-Y, Cheng S-J, Lin P-Y, Wang R-Y. Relationships between gait and dynamic balance in early Parkinson's disease. Gait Posture . 2008;27(4):611-5.
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31
ORIGINAL_ARTICLE
The Effect of Eccentric Exercise Induced Muscle Damage at Different Times on Mitsogomin53 and Dysferlin Levels in Rat Soleus Muscle
Eccentric contraction during exercise causes muscle and sarcolemma damage. Mitsogomin53 and Dysferlin are the major sarcolemma repair proteins. Therefore, the aim of the present study was to investigate the effect of eccentric exercise-induced muscle damage at different times on skeletal muscle Mitsogomin53 and Dysferlin. Fifty male Wistar rats, after familiarization with the environment and the treadmill were divided into five control groups and five eccentric exercise groups. Soleus muscle in sterile conditions disassociate half, 24, 48, 72 and 168 hours (one week) after eccentric exercise (90 min interval running with 16 meter/min and -16 degree slope). Hematoxylin-eosin and western blotting methods were used to measure the number of inflammatory cells and extract the proteins of Mitsogomin53 and Dysferlin. Two-way ANOVA and independent t-test were used to compare the means with the significance level of p≤0.05. The number of inflammatory cells, Mitsogomin53 and Dysferlin proteins at the half, 24, 48, 72 and 168 hours (one week) after eccentric exercise in the exercise group were significantly higher than the control group (p
https://jsb.ut.ac.ir/article_75431_daecbd90fa01bbf041396bccc8b4779d.pdf
2020-11-21
277
290
10.22059/jsb.2020.295552.1377
EIMD
Dysferlin
inflammatory cells
Eccentric Exercise
Mitsogomin53
Tohid
Hemmatzade Beddovli
t.hematzade@gmail.com
1
PhD Student, Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
AUTHOR
Maryam
Nourshahi
m-nourshahi@sbu.ac.ir
2
Associate Professor, Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
LEAD_AUTHOR
Raana
Fayyaz Milani
r_milani@sbu.ac.ir
3
Assistant Professor, Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
AUTHOR
Siavash
Parvardeh
parvardehs@sbmu.ac.ir
4
. Associate Professor, Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
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40. Nunes-Silva A, Bernardes PT, Rezende BM, Lopes F, Gomes EC, Marques PE, et al. Treadmill exercise induces neutrophil recruitment into muscle tissue in a reactive oxygen species-dependent manner. An intravital microscopy study. PLoS One. 2014;9(5).
40
41. Pizza F. Peterson JM, Baas JH, Koh TJ. Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice J Physiol. 2005;562:899-913.
41
42. Qun Zuo S-CW, Xin-Kai Yu, Wei-Wei Chao. Response of macrophages in rat skeletal muscle after eccentric exercise. Chinese Journal of Traumatology. 2018:1-8.
42
ORIGINAL_ARTICLE
The Effect of Aerobic and Resistance Training with Different dose of Methadone on Fibrinogen and Lipid Profile in Addicted Men
Background and Aim: Effective use of medications as methadone with exercise training can facilitate the development of healthy. The aim of this study was to compare the effect of different training with methadone on fibrinogen and lipid profile of addicted men.Methodology: 90 addicted men are treated in prison (36.8 ± 4.3yrs) were randomly divided into six groups (n=15): control, Narcotics Anonymous(NA), aerobic training + methadone, aerobic training + methadone reduction, resistance training + methadone, Resistance training + methadone reduction. Experimental groups performed training for 12 weeks, three sessions in week. Aerobic training consisted of 4 to 8 sets, 3-min at 80–90 % maximum heart rate (HRmax) on a cycle ergometer. Resistance training performed with 8 to 12 repetitions, 3 sets and 70-85% one repetition maximum(1RM). Data were analyzed by SPSS software and Multiple analysis of variance (MANOVA) and Tukey post hoc test at the significant level (P≤0.05).Results: The high-density lipoproteins (HDL) level of blood in the training groups was significantly increased (P≤00001) compared to the control group. Also, low-density lipoproteins (LDL, P≤0.005), Triglycerides (TG, P≤0/008), Total Cholesterol (P≤0/014 and fibrinogen (P≤00001) levels were significantly reduced in the training groups compared to the control group. Also, the aerobic training groups had a greater effect of all the measured variables than the resistance training.Conclusion: regular exercise, especially aerobic and resistance exercises with a reduction in methadone has a favorable effect on inflammatory factors and ultimately the health of addicted people
https://jsb.ut.ac.ir/article_78541_f5349a8e99227cc22f1c6dbe62d5f96f.pdf
2020-11-21
291
305
10.22059/jsb.2020.295430.1376
Aerobic and Resistance training"
" Fibrinogen"
" Lipid profile "
" Methadone
"Withdrawal addiction
Rasoul
Chegol
rasoul15072@gmail.com
1
Ph.D. Student, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
AUTHOR
Mandana
gholami
gholami_man@yahoo.com
2
. Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences,
LEAD_AUTHOR
Hasan
Matin Homaee
hasanmatinhomaee@gmail.com
3
Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Islamic Azad University, Tehran Central Branch, Tehran, Iran
AUTHOR
Hosein
Abednatanzi
abednazari@gmail.com
4
Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
AUTHOR
Farshad
Ghazalian
phdghazalian@gmail.com
5
Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
AUTHOR
1. Bonakdaran S, Akbari Rad M, Hasanzadeh Deloie M, Akhoondpoor manteghi M, Firoozi A. QTc Prolongation in Methadone Users and Its Relation with Hormonal Changes. Medical Journal of Mashhad University of Medical Sciences. 2017;60(2):441-9.
1
2. Feizi Manesh B, Yarahmadi Y. A Survey of the Effect of Methadone Maintenance Treatment (MMT) on Cognitive Functions of Opioid-dependent Patients in Central prison of Hamedan. Middle Eastern Journal of Disability Studies. 2017;7(0):16-.
2
3. Vestal-Laborde A, Eschenroeder A, Bigbee J, Robinson S, Sato-Bigbee C. The Opioid System and Brain Development: Effects of Methadone on the Oligodendrocyte Lineage and the Early Stages of Myelination. Developmental Neuroscience. 2014;36.
3
4. Aghili M, Moloodi M, Afshar H, Salehi M, Hasanzadeh A, Adibi P. Prevalence of Gastrointestinal Symptoms in Opioid Consumers Referring to Methadone Maintenance Treatment (MMT) Clinics in Isfahan, Iran. Journal of Isfahan Medical School. 2013;31:843-50.
4
5. Khalili M, Ghosian MH, Niknam A. Study and Comparison of the Effect of Oral Administration of Peganum Harmala Seeds and Methadone on Morphine Withdrawal Syndrome in Rats. Pathobiology Research. 2010;13(1):37-46.
5
6. Greeneltch K, Kelly-Welch A, Shi Y, Keegan A. Chronic Morphine Treatment Promotes Specific Th2 Cytokine Production by Murine T Cells In Vitro via a Fas/Fas Ligand-Dependent Mechanism. Journal of immunology (Baltimore, Md : 1950). 2005;175:4999-5005.
6
7. Loui monfared A, Mami S, Salati AP. The Effect of the Opium Addiction on Histological Structure of Liver and Kidney in Rabbits. Journal of Ilam University of Medical Sciences. 2013;21(3):39-45.
7
8. Donges C, Duffield R, Drinkwater E. Effects of Resistance or Aerobic Exercise Training on Interleukin-6, C-Reactive Protein, and Body Composition. Medicine and Science in Sports and Exercise. 2010;42:304-13.
8
9. Timmons B, Bar-Or O. Growth-Related Changes in the Acute Immune Response to Exercise in Healthy Boys. Medicina Sportiva. 2008;12:92-8.
9
10. Khademi A, Tofighi A, Tolouei azar J, Saify Nabiabad H, Nouri Habashi A. Modulation of Blood Hemostasis by Concurrent Training in Obese Women with Low-mobility. Studies in Medical Sciences. 2019;29(11):781-92.
10
11. barzegari H, Choobineh S, akbarnejad a, rahimzadeh h. The Effect of Endurance Training on Some Inflammatory Markers in Male Smokers. Sport Physiology & Management Investigations. 2018;10(2):21-30.
11
12. Somkuwar SS, Staples MC, Fannon MJ, Ghofranian A, Mandyam CD. Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior. Brain Plast. 2015;1(1):63-81.
12
13. Zou L, Pan Z, Yeung A, Talwar S, Wang C, Liu Y, et al. A Review Study on the Beneficial Effects of Baduanjin. The Journal of Alternative and Complementary Medicine. 2018;24(4):324-35.
13
14. Pouladi S, Bagherpour Borazjani A, Motamed N, Amini A, Rahbar A, Vahedparast H, et al. A Survey on the Effect of Psyllium on Serum Levels of Triglycerid and Lipoproteins. Iranian South Medical Journal. 2009;11(2):139-46.
14
15. SAREMI A. Sporting Exercies and Diabetes Mellitus Type 2: a Review on Evidences. Journal of Cell and Tissue. 2011;2(3):-.
15
16. Najafipour H, Joukar S, Malekpour-Afshar R, Mirzaeipour F, Nasri HR. Passive Opium Smoking Does not have Beneficial Effect on Plasma Lipids and Cardiovascular Indices in Hypercholesterolemic Rabbits with Ischemic and Non-ischemic Hearts. J Ethnopharmacol. 2010;127(2):257-63.
16
17. Abbasi Moghdam M, Keshvari M, Tahramuzi MA. The Effect of 8 Weeks Aerobic Training on Changes Beta-endorphin, Cortisol, Growth Hormone Levels and Anthropometric Factors in Recovering Addicts. Medical Journal of Tabriz Univercity of Medical Science. 2019;40(60 #T00182):-.
17
18. Fathi M, Mir E. The Effect of 12 Resistance Training Sessions on Some Coagultion and Fibrinolytic Factors In Non-active Men. Journal Of PracticalL Studies at Biosciences in Sport. 2015;3(5):-.
18
19. Vakili J, Hosseinpour L. The Effect of 8 Weeks Aerobic Exercise Traning along with Green Tea Consumption on the Cardiovascular Risk in Obese Women. Journal of Practical Studies at Biosciences in Sport. 2015;3(5):-.
19
20. Nash MS, Jacobs PL, Mendez AJ, Goldberg RB. Circuit Resistance Training Improves the Atherogenic Lipid Profiles of Persons with Chronic Paraplegia. The Journal of Spinal Cord Medicine. 2001;24(1):2-9.
20
21. Mirzaeipour F, Azdaki N, Mohammadi G, Oshaghi E. The Effects of Opium Addiction through Different Administration Routes on Inflammatory and Coagulation Factors. Journal of Kerman University of Medical Sciences. 2013;20:292-300.
21
22. Moloudi A, Sabzi F, Shahhosaini E. Analysis of Coagulation Tests, Proteins C and S, and Plasma Fibrinogen in Addicts and Non-addicts with Coronary Artery Disease. Journal of Kermanshah University of Medical Sciences. 2014;17(12):e74287.
22
23. Maesomi M, Nasri HR, Farajpour F. Comparison of Plasma Fibrinogen Level in Opium Addict Men with Non-addict men. Journal of Kerman University of Medical Sciences. 2001;8(1):27-31.
23
24. Dehghan S, Sharifi GR, Faramarzi M. The Effect of Eight Week Low Impact Rhythmic Aerobic Training on Total Plasma Homocysteine Concentration in Older Non-athlete Women. Journal of Mazandaran University of Medical Sciences. 2009;19(72):53-9.
24
25. Saremi A, Khalaji H, Momeni S. Effect of Resistance Training on Serum Level of C-Reactive Protein (CRP) and Fibrinogen in Male Addicts. Research on Addiction. 2016; 9(36):111-24.
25
26. Kamath S, Lip GY. Fibrinogen: Biochemistry, Epidemiology and Determinants. QJM: An International Journal of Medicine. 2003;96(10):711-29.
26
27. Ghanei AM, Saadatnia M, Javanmard S. Effects of opium addiction on vascular endothelium. Journal of Isfahan Medical School. 2013;30:2084-90.
27
28. Haddadi F, Jazizadeh-Karimi M, Rostami Nejad M, Sokhtehzari S, Monazami AH, Asad MR. The Effect of Endurance Training on Addicted Women’s Level of Alkaline Phosphates Who Use Methadone. Report of Health Care. 2015;1(2):44-6.
28
29. Torabi S, Asad MR, Tabrizi A. The Effect of 8 Weeks of Moderate-Intensity Endurance Training on Serum Levels of Liver Enzymes and Insulin Resistance Index in Women with Type 2 Diabetes. Qom University of Medical Sciences Journal. 2017;11(7):47-55.
29
ORIGINAL_ARTICLE
Comparison of the Effect of high-Intensity Interval training (HIIT) and Moderate-Intensity Continuous Training (MICT) on Syndrome Metabolic Factors in Menopause Obese Women with Metabolic Syndrome
The present study conducted to compare the effect of high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) with regard to variables associated syndrome metabolic in menopause obese women. In a semi-experimental with pre-test and post-test design, 40 voluntary menopause obese women with metabolic syndrome, randomly assigned into three groups of control, MICT (3 days/wk of 25-30 min aerobic exercise at 40%–65% heart rate reserve(HRR)) and HIIT (3 days/wk of 6-12 × 60 s of high intensity training (85–95% HRR)) + running for 60 s at low intensity (55–60% of HRR )) exercise program for 12 weeks. Before training and after the last training bout body compoeition indices and blood samples of subjects were evaluated. The results showed that both HIIT and MICT groups showed a significant effect on weight, BMI, body Fat percent, waist circumference (WC), WHR, triglycerides, colestrol, LDL-C, HDL-C, fasting blood glucose, insulin and HOMA-IR (p0.05). Moreover, compared to MICT, HIIT demonstrated greater reduction in weight (p=0.003), BMI (p=0.003) body Fat percent (p=0.000), WC (p=0.006), triglycerides (p=0.041), insulin (p=0.022) and HOMA-IR (p=0.012). Taken together, our data suggest that despite of the effectiveness of both training program, compared to MICT, HIIT appears to be the predominant strategy for greater improvements in markers of syndrome metabolic in menopause obese women.
https://jsb.ut.ac.ir/article_77862_7e37bd27d3d93afee52f6a9ec51f9de1.pdf
2020-11-21
307
328
10.22059/jsb.2020.297304.1385
Body compositon
Exercise Training
insulin resistance. menopause women
syndrome metabolic
Sirvan
Atashak
sirvan.atashak@gmail.com
1
. Associate Professor of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran
LEAD_AUTHOR
Reza
Roshdi Bonab
rezaroshdi@yahoo.com
2
Assistant Professor of Exercise Physiology, Bonab Branch, Islamic Azad University, Bonab, Iran
AUTHOR
Vahideh
Kianmarz Bonab
vkianmarz@gmail.com
3
. Assistant Professor of Exercise Physiology, Payame Noor University, Tehran, Iran
AUTHOR
1. Karvinen SM, Jergenson MJ, Hyvärinen MV, Aukee P, Tammelin TH, Sipilä S, et al. Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women: cross-sectional and longitudinal evidence. Frontiers in endocrinology. 2019;10:589.
1
2. Zhou H, Zhang C, Ni J, Han X. Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal inpatients with type 2 diabetes mellitus in China. BMC endocrine disorders. 2019;19(1):98.
2
3. He L, Tang X, Li N, Wu Y, Wang J, Li J, et al. Menopause with cardiovascular disease and its risk factors among rural Chinese women in Beijing: a population-based study. Maturitas. 2012;72(2):132-8.
3
4. Gurka MJ, Vishnu A, Santen RJ, DeBoer MD. Progression of metabolic syndrome severity during the menopausal transition. Journal of the American Heart Association. 2016;5(8):e003609.
4
5. Marchi Rd, Dell’Agnolo CM, Lopes TCR, Gravena AAF, Demitto MdO, Brischiliari SCR, et al. Prevalence of metabolic syndrome in pre-and postmenopausal women. Archives of endocrinology and metabolism. 2017;61(2):160-6.
5
6. Mazloomzadeh S, Zarandi FK, Shoghli A, Dinmohammadi H. Metabolic syndrome, its components and mortality: A population-based study. Medical journal of the Islamic Republic of Iran. 2019;33:11.
6
7. Jahangiry L, Khosravi-far L, Sarbakhsh P, Kousha A, EntezarMahdi R, Ponnet K. Prevalence of metabolic syndrome and its determinants among Iranian adults: evidence of IraPEN survey on a bi-ethnic population. Scientific reports. 2019;9(1):1-7.
7
8. Rohani H, AZALI AK, Helalizadeh M. EFFECT OF AEROBIC TRAINING ON OVERALL METABOLIC RISK AND INDICES LEVELS IN PATIENTS WITH METABOLIC SYNDROME: A META-ANALYSIS STUDY. Sport Physiology &Management Investigations. 2016;8(31):14-44.
8
9. Ferns GA, Ghayour-Mobarhan M. Metabolic syndrome in Iran: a review. Translational Metabolic Syndrome Research. 2018;1:10-22.
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10. Raczkiewicz D, Owoc A, Wierzbińska-Stępniak A, Bojar I. Metabolic syndrome in peri-and postmenopausal women performing intellectual work. Ann Agric Environ Med. 2018;25(4):610-5.
10
11. Faulkner JL, de Chantemèle EJB. Sex hormones, aging and cardiometabolic syndrome. Biology of sex differences. 2019;10(1):30.
11
12. Mehrabani J, Mirmohamadloo F, Nobari H. The Effect of 8 Weeks of Circuit Resistance Training on Ox-LDL, hs-CRP, HbA1c and Insulin Resistance Index in Sedentary Postmenopausal Women. Sport Physiology &Management Investigations. 2017;8(4):47-57.
12
13. Gallo-Villegas J, Aristizabal JC, Estrada M, Valbuena LH, Narvaez-Sanchez R, Osorio J, et al. Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET). Trials. 2018;19(1):144.
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14. Keshel TE, Coker RH. Exercise training and insulin resistance: a current review. Journal of obesity & weight loss therapy. 2015;5(0 5):S5-003.
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15. Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes & development. 2007;21(12):1443-55.
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16. Esteghamati A, Khalilzadeh O, Rashidi A, Kamgar M, Meysamie A, Abbasi M. Physical activity in Iran: results of the third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007). Journal of Physical Activity and Health. 2011;8(1):27-35.
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17. Vekic J, Zeljkovic A, Stefanovic A, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V. Obesity and dyslipidemia. Metabolism. 2019;92:71-81.
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19. Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, et al. Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis. Jama. 2016;315(22):2424-34.
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20. Kasch J, Schumann S, Schreiber S, Klaus S, Kanzleiter I. Beneficial effects of exercise on offspring obesity and insulin resistance are reduced by maternal high-fat diet. PloS one. 2017;12(2):e0173076.
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21. Joseph MS, Tincopa MA, Walden P, Jackson E, Conte ML, Rubenfire M. The Impact Of Structured Exercise Programs On Metabolic Syndrome And Its Components: A Systematic Review. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;12:2395.
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22. Beqa Ahmeti G, Idrizovic K, Elezi A, Zenic N, Ostojic L. Endurance Training vs. Circuit Resistance Training: Effects on Lipid Profile and Anthropometric/Body Composition Status in Healthy Young Adult Women. International Journal of Environmental Research and Public Health. 2020;17(4):1222.
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23. Azali Alamdari K. Effects of 8 weeks of high intensity interval and moderate intensity continuous training on serum ICAM-1, CRP and cardiometabolic risk factors in middle-agedmen. Journal of Practical Studies of Biosciences in Sport. 2018;6(12):83-101.
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26. Khoramjah M, Khorshidi D, Karimi M. Effect of Moderate-Intensity Aerobic Training on Some Hormonal and Metabolic Factors Associated With Breast Cancer in Overweight Postmenopausal Women. Salmand: Iranian Journal of Ageing. 2019;14(1):74-83.
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27. Abolfathi F, Ranjbar R, Shakerian S, Yazdan Panah L. The Effect of Eight Weeks Aerobic Interval Training on Adiponectin Serum Levels, Lipid Profile and HS-CRP in Women With Type II diabetes. Iranian Journal of Endocrinology and Metabolism. 2015;17(4):316-24.
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28. Huang PL. A comprehensive definition for metabolic syndrome. Disease models & mechanisms. 2009;2(5-6):231-7.
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31. Cuddy TF, Ramos JS, Dalleck LC. Reduced exertion high-intensity interval training is more effective at improving cardiorespiratory fitness and cardiometabolic health than traditional moderate-intensity continuous training. International journal of environmental research and public health. 2019;16(3):483.
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38. Skleryk J, Karagounis L, Hawley J, Sharman MJ, Laursen PB, Watson G. Two weeks of reduced‐volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism. 2013;15(12):1146-53.
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39. Krawcyk RS, Vinther A, Petersen NC, Faber J, Iversen HK, Christensen T, et al. Effect of Home-Based High-Intensity Interval Training in Patients With Lacunar Stroke: A Randomized Controlled Trial. Frontiers in neurology. 2019;10:664.
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40. Dun Y, Thomas RJ, Smith JR, Medina-Inojosa JR, Squires RW, Bonikowske AR, et al. High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction. Cardiovascular diabetology. 2019;18(1):104.
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53. Moholdt TT, Amundsen BH, Rustad LA, Wahba A, Løvø KT, Gullikstad LR, et al. Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life. American heart journal. 2009;158(6):1031-7.
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55. Whyte LJ, Gill JM, Cathcart AJ. Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men. Metabolism. 2010;59(10):1421-8.
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56. Little JP, Jung ME, Wright AE, Wright W, Manders RJ. Effects of high-intensity interval exercise versus continuous moderate-intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Applied physiology, nutrition, and metabolism. 2014;39(7):835-41.
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61
ORIGINAL_ARTICLE
The Effect of Two-month Concurrent Training with and without Calorie Restriction on Sirtuin-1 Activity and Content in the Peripheral Blood Mononuclear Cells of Inactive Men
AbstractSirtuins have become prominent molecules in the aging process. Therefore, the present study was conducted to compare the effect of two months of concurrent training with and without calorie restriction on sirtuin-1 activity and content in the peripheral blood mononuclear cells (PBMCs) of inactive men. Therefore, thirty inactive men participated in three homogeneous groups: calorie restriction (CR: n=10), concurrent training (T: n=10), and concurrent training with calorie restriction (TCR: n=10). The calorie restriction was about -30 kcal•kg-1•week-1. The training consisted of five days a week (Resistance Training: two sessions / week-1, and High- Intensity Interval Training: three sessions / week-1). Sirtuin-1 content and activity in PBMCs were measured by ELISA and fluorometric assay, respectively. To measure oxidative stress, Plasma total antioxidant capacity (TAC) and serum malondialdehyde (MDA) levels were determined by FRAP and spectrophotometry, respectively. Data were analyzed using analysis of variance at a significance level ≤ 0.05. The results showed that Sirtuin-1 activity and TAC of all three groups were significantly increased after two-month interventions (p < 0.05). However, the changes in sirtuin-1 content and MDA levels were not significant in any groups (P> 0.05). Given the optimal changes in sirtuin-1 activity in PBMCs, TAC, and somebody composition components following two-months of concurrent training without calorie restriction, it can be concluded that concurrent training may be a more appropriate intervention for modulating the cell survival indicator in inactive men.
https://jsb.ut.ac.ir/article_77801_417d42f9df69d19cd47626ff9278d4f5.pdf
2020-11-21
329
345
10.22059/jsb.2020.308308.1422
exercise
Aging
Cell Survival
Diet Therapy
oxidative stress
Afshar
Jafari
af_jafari@sbu.ac.ir
1
. Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran, b: Associate Professor of Exercise Physiology, Department of Biological Sciences in Sport,
LEAD_AUTHOR
Farid
Etemadian
etemadianfarid@gmail.com
2
. PhD Student, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
AUTHOR
Ali Akbar
Malekirad
malekirad@tabrizu.ac.ir
3
. Associate Professor of Physiology, Department of Biology, Faculty of Science, Payame Noor University, Tehran, Iran
AUTHOR
Behzad
Baradaran
baradaranb@tbzmed.ac.ir
4
Associate Professor of Immunology, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
1. DESA U. United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects 2019: Highlights. 2019.
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11. Liu H-W, Kao H-H, Wu C-H. Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic db/db mice. Nutrition & metabolism. 2019;16(1):1-10.
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12. Suwa M, Nakano H, Radak Z, Kumagai S. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism. 2008;57(7):986-98.
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13. Dumke CL, Davis JM, Murphy EA, Nieman DC, Carmichael MD, Quindry JC, et al. Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis. European journal of applied physiology. 2009;107(4):419.
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14. Huang C-C, Wang T, Tung Y-T, Lin W-T. Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age. International journal of medical sciences. 2016;13(4):260.
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15. Palee S, Minta W, Mantor D, Sutham W, Jaiwongkam T, Kerdphoo S, et al. Combination of exercise and calorie restriction exerts greater efficacy on Cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation. Metabolism. 2019;94:77-87.
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17. Baar K. Using molecular biology to maximize concurrent training. Sports Medicine. 2014;44(2):117-25.
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18. Roldan M, Agerholm M, Nielsen TS, Consitt LA, Søgaard D, Helge JW, et al. Aerobic and resistance exercise training reverses age‐dependent decline in NAD+ salvage capacity in human skeletal muscle. Physiological reports. 2019;7(12).
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24. Kilic U, Gok O, Erenberk U, Dundaroz MR, Torun E, Kucukardali Y, et al. A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human. PloS one. 2015;10(3):e0117954.
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28. Mansur AP, Roggerio A, Goes MF, Avakian SD, Leal DP, Maranhão RC, et al. Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial. International journal of cardiology. 2017;227:788-94.
28
29. Ma JK, Scribbans TD, Edgett BA, Boyd JC, Simpson CA, Little JP, et al. Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle. Open Journal of Molecular and Integrative Physiology. 2013;3(04):202.
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31. Gurd BJ, Yoshida Y, McFarlan JT, Holloway GP, Moyes CD, Heigenhauser GJ, et al. Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2011;301(1):R67-R75.
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34
ORIGINAL_ARTICLE
Effect of Spinal Nerve Ligation (SNL) on the Expression of TRAF6 and MuRF1 Genes in soleus Mucsle of Wistar Rats after HIT Training
The purpose of the present study was to investigate the effect of SNL on the expression of TRAF6 muRF1 genes in the Soleus muscle of Wistar rats after HIT traning. For this purpose, 24 male rats were divided into 2 groups of control (C) (n=12) and training (HIT) (n=12). After one-week familiarization, training group participate in four HIT training. Then, they were randomly assigned to HIT (n=6) and HIT-SNL (n=6) groups. At the same time, the control group was divided into two groups: control (C) (n=6) and spinal cord nerve (C-SNL) (n=6). 4 weeks after the SNL, wistar rats were sacrificed and soleuse muscle exetracted.Then Gene expressions of MuRF1 and TRAF6 measured Real time PCR technique. The results showed that inactivity by SNL has a significant effect on the expression of TRAF6 and MuRF1 genes (P=0.0001 and P=0.0001, respectively). Also, performed before SNL reduced the expression of TRAF6 and MuRF1 (P=0.003 and P=0.0001 respectively). In addition, the findings indicated that SNL had a significant effect on the weight of Soleus muscle mass/ tibia length (P=0.01). On the other hand, HIT training before SNL significantly increased weight of Soleus muscle mass/ tibia length (P = 0.03). Therefore, the decrease in activity by SNL is associated with increased in expression of TRAF6 and MuRF1 genes, which may also be involved in muscle mass changes. Regarding the fact that performing HIT reduces the expression of these genes in soleus muscle, these training can be used to maintain obtimal muscle mass before physical activity.
https://jsb.ut.ac.ir/article_78241_591dca78c1dee38522797ecfb63704c0.pdf
2020-11-21
347
362
10.22059/jsb.2020.297768.1384
SNL
تمرین تناوبی
MuRF1
TRAF6
Abdolreza
Kazemi
rkazemi22@yahoo.com
1
Associate Professor in Exercise Physiology, Department of Sport Sciences, Faculty of Literature and Humanities, Vali E-Asr University, Rafsanjan, Iran
LEAD_AUTHOR
Alireza
Saeed
alireza_saiid@vru.ac.ir
2
. a) MSc Student, Department of Exercise Physiology, Islamic Azad University, Kerman, Iran, b) Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
1. Bize, R., J.A. Johnson, and R.C. Plotnikoff, Physical activity level and health-related quality of life in the general adult population: a systematic review. Preventive medicine, 2007. 45(6): p. 401-415.
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5. Fanzani, A., et al., Molecular and cellular mechanisms of skeletal muscle atrophy: an update. Journal of cachexia, sarcopenia and muscle, 2012. 3(3): p. 163-179.
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6. Jespersen, J., et al., Myostatin expression during human muscle hypertrophy and subsequent atrophy: increased myostatin with detraining. Scandinavian journal of medicine & science in sports, 2011. 21(2): p. 215-223.
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7. Paul, P.K., et al., Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. Journal of Cell Biology, 2010. 191(7): p. 1395-1411.
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8. Chung, J.Y., et al., Molecular basis for the unique specificity of TRAF6, in TNF Receptor Associated Factors (TRAFs). 2007, Springer. p. 122-130.
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9. Zapata, J.M., S. Lefebvre, and J.C. Reed, Targeting TRAfs for therapeutic intervention, in TNF Receptor Associated Factors (TRAFs). 2007, Springer. p. 188-201.
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16. Gielen, S., et al., Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation, 2012. 125(22): p. 2716-2727.
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17. Drey, M., et al., Motoneuron loss is associated with sarcopenia. Journal of the American Medical Directors Association, 2014. 15(6): p. 435-439.
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18. Glass, D.J., Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nature cell biology, 2003. 5(2): p. 87-90.
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19. Aguiar, A., et al., High-intensity physical exercise disrupts implicit memory in mice: involvement of the striatal glutathione antioxidant system and intracellular signaling. Neuroscience, 2010. 171(4): p. 1216-1227.
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20. Nytrøen, K., et al., High‐Intensity Interval Training Improves Peak Oxygen Uptake and Muscular Exercise Capacity in Heart Transplant Recipients. American Journal of Transplantation, 2012. 12(11): p. 3134-3142.
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21. Gillen, J.B., et al., Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health. PLoS One, 2014. 9(11): p. e111489.
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22. Laursen, P.B. and D.G. Jenkins, The scientific basis for high-intensity interval training. Sports Medicine, 2002. 32(1): p. 53-73.
22
23. Miyamoto-Mikami, E., et al., Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men. Scientific reports, 2018. 8(1): p. 1-14.
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24. Winter, B., et al., High impact running improves learning. Neurobiology of learning and memory, 2007. 87(4): p. 597-609.
24
25. Aguiar, A.S., et al., Downhill training upregulates mice hippocampal and striatal brain-derived neurotrophic factor levels. Journal of neural transmission, 2008. 115(9): p. 1251-1255.
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26. Kim, S.H. and J.M. Chung, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain, 1992. 50(3): p. 355-363.
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27. Hafstad, A.D., et al., High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. Journal of Applied Physiology, 2011. 111(5): p. 1235-1241.
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29. Nilwik, R., et al., The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Experimental gerontology, 2013. 48(5): p. 492-498.
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31. Rowan, S.L., et al., Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle. PloS one, 2012. 7(1): p. e29082.
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32. Verdijk, L.B., et al., Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly. American Journal of Physiology-Endocrinology and Metabolism, 2007. 292(1): p. E151-E157.
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33. Bonaldo, P. and M. Sandri, Cellular and molecular mechanisms of muscle atrophy. Disease models & mechanisms, 2013. 6(1): p. 25-39.
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34. Sandri, M., et al., Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology, 2013. 14(3): p. 303-323.
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35. Labeit, S., et al., Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice. Journal of Biomedicine and Biotechnology, 2010. 2010.
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36. Al-Nassan, S., et al., Chronic exercise training down-regulates TNF-α and atrogin-1/MAFbx in mouse gastrocnemius muscle atrophy induced by hindlimb unloading. Acta Histochemica et Cytochemica, 2012. 45(6): p. 343-349.
36
37. Labeit, S., et al., Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice. BioMed Research International, 2010. 2010.
37
38. Polge, C., et al., UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension. The international journal of biochemistry & cell biology, 2016. 79: p. 488-493.
38
39. Paul, P.K., et al., Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. The Journal of cell biology, 2010. 191(7): p. 1395-1411.
39
40. Cai, D., et al., IKKβ/NF-κB activation causes severe muscle wasting in mice. Cell, 2004. 119(2): p. 285-298.
40
41. Li, H., S. Malhotra, and A. Kumar, Nuclear factor-kappa B signaling in skeletal muscle atrophy. Journal of molecular medicine, 2008. 86(10): p. 1113-1126.
41
42. Bilodeau, P.A., E.S. Coyne, and S.S. Wing, The ubiquitin proteasome system in atrophying skeletal muscle: roles and regulation. American Journal of Physiology-Cell Physiology, 2016. 311(3): p. C392-C403.
42
43. Mittal, A., et al., The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. The Journal of cell biology, 2010. 188(6): p. 833-849.
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44
45. Sadri, S., G. Sharifi, and K.J. Dehkordi, Effects of high intensity interval training (up&downward running) with BCAA/nano chitosan on Foxo3 and SMAD soleus muscles of aging rat. Life Sciences, 2020: p. 117641.
45
46. Kazemi, A. and E. Jahanshahi, Effect of Spinal Nerve Ligation on The Expression of Tweak and Fn14 Genes in EDL Mucsle of Wistar Rats After HIT Training.
46
ORIGINAL_ARTICLE
The Effect of 6 Weeks of Aerobic Training and Aqueous Extract of Caraway Seed on Serum Level of Adipolin and Lipid Profile Changes in Obese Male Rats
Adipolin is an anti-inflammatory adipocytokine secreted from adipose tissue. Due to the role of medicinal plants in controlling obesity, this study was conducted to determine the effect of 6 weeks of aerobic training and aqueous extract of caraway seed on serum level of adipolin and lipid profile changes in obese male rats.In this experimental study, 24 obese male rats were used after 12 weeks of high-fat diet; they were randomly divided into 4 groups: 1. control 2. training 3. carawayextract 4. training + carawayextract. The training groups performed aerobic training for 6 weeks, 5 days a week (55% VO2max). Serum level of adipolin, lipid profile changes and body weight were measured. Data were analyzed using one-way ANOVA and Tukey's post hoc test. The results showed significant decreases in body weight, LDL-C, TG, TC (P<0.05) and significant increases in serum level of adipolin and HDL-C (P<0.05) in the training + carawayextract compared to other groups. According to the results, it seems that moderate intensity aerobic training and aqueous extract of caraway seed can lead to weight loss with an increase in serum level of adipolin and HDL-C and a decrease in LDL-C, TG and TC.
https://jsb.ut.ac.ir/article_78240_2cd4270e4cf1f896d8bac77452d8094f.pdf
2020-11-21
362
374
10.22059/jsb.2020.306117.1411
Adipolin
Aerobic training
Caraway
lipid profile
Sedigheh
Taherzadeh
s68taherzadeh@gmail.com
1
PhD of Exercise Physiology, Faculty Member of Department of Physical Education, Fatemeh Zahra Vocational School, Technical and Vocational University (TVU) , Kerman, Iran
AUTHOR
Mehdi
Mogharnasi
m_mogharnasi@yahoo.com
2
Associate Professor, Department of Sport Sciences, University of Birjand, Birjand, Iran
LEAD_AUTHOR
Bahram
Rasoulian
bahramrasoulian@gmail.com
3
Professor, Department of Physiology, Lorestan University of Medical Sciences, Lorestan, Iran
AUTHOR
Ayat
Kaeidi
a.kayedi@gmail.com
4
Assistant Professor, Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
AUTHOR
1. Valizadeh E, Ostadrahimi A. The Effect of herbal supplement'Mohazzel'in traditional medicine and weight loss diet on some biochemical parameters & Anthropometric indices in obese subjects. Complementary Medicine Journal of faculty of Nursing & Midwifery. 2018;7(4):2115-27. (in persian)
1
2. Pourahmadi M, Jahromi H, Rooeintan Y. The effect of aqueous extract of caraway seed (Carum carvi) on cholecystokinin hormone in male rat. Journal of Fundamental and Applied Sciences. 2016;8(4):2023-35.
2
3. Keating SE, Hackett DA, Parker HM, O’Connor HT, Gerofi JA, Sainsbury A, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. Journal of hepatology. 2015;63(1):174-82.
3
4. Rahmatollahi M, Ravasi A, Soori R. Effect of 8 Weeks of Low-Intensity Continuous Training on Plasma Adipolin, Insulin Resistance, and Weight of Fatty Fat-Filled Rats. Adv Obes Weight Manag Control. 2017;7(5):00211.
4
5. Fadaei R, Moradi N, Kazemi T, Chamani E, Azdaki N, Moezibady SA, et al. Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance. Cytokine. 2019;113:326-31.
5
6. Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, et al. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. Journal of Biological Chemistry. 2012;287(13):10301-15.
6
7. Soori R AMR, Khosravi M, Abbasian S. The Effect of Submaximal Aerobic Training on Serum Irisin Level in Obese Men; with Emphasis on the Role of Irisin in Insulin-Resistance Change. Arak Medical University Journal (AMUJ). 2016;19(109):20-30. (in persian)
7
8. Haidari F, Seyed-Sadjadi N, Taha-Jalali M, Mohammed-Shahi M. The effect of oral administration of Carum carvi on weight, serum glucose, and lipid profile in streptozotocin-induced diabetic rats. Saudi Med J. 2011;32(7):695-700.
8
9. Kazemipoor M, Hajifaraji M, Haerian BS, Mosaddegh MH, Cordell GA. Antiobesity effect of caraway extract on overweight and obese women: a randomized, triple-blind, placebo-controlled clinical trial. Evidence-Based Complementary and Alternative Medicine. 2013;2013.
9
10. Mahboubi M. Caraway as Important Medicinal Plants in Management of Diseases. Natural products and bioprospecting. 2019;9(1):1-11.
10
11. Ghorbani S, Alizadeh R, Moradi L. The effect of high intensity interval training along with consumption of caraway seeds (Carum carvi L.) on liver enzymes, lipid profile, and blood glucose in obese and overweight women. 2017. (in persian)
11
12. Zare R HF, Fallahzadeh H, Nadjarzadeh A. Effect of cumin powder on body composition and lipid profile in overweight and obese women. Complementary therapies in clinical practice. 2014;20(4):297-301.
12
13. Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutrition research reviews. 2010;23(2):270-99.
13
14. Hamedifar M, Mirnasouri R, Rahmati M. The Effects of Six Weeks Endurance Training on XBP-1 Protein in the Diabetic Male Wistar Rats Sciatica Tissues. Iranian Journal of Diabetes and Obesity. 2018; 10(4):187-193. (in persian)
14
15. Taherzadeh S, Mogharnasi M, Rasoulian B, Kaeidi A, Khosravi A. The Effect of 6 Weeks Aerobic Training and Aqueous Extract of Caraway Seed (Carum Carvi) on the Expression of CTRP12 Gene, Body Weight Changes and Subcutaneous Adipose Tissue in Obese Male Rats: An Experimental Study. Journal of Rafsanjan University of Medical Sciences. 2020;19(1):39-52. (in persian)
15
16. Hoshmand F FM ZS. The effect of oxytocin on oxidative stress induced myocardial ischemia-reperfusion in rats. Journal of Endocrinology and Metabolism. 2011;12(6):633-40. (in persian)
16
17. Welc SS, Clanton TL. The regulation of interleukin‐6 implicates skeletal muscle as an integrative stress sensor and endocrine organ. Experimental physiology. 2013;98(2):359-71.
17
18. Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Medicine. 2018;48(2):269-88.
18
19. Rezaeian N, Ravasi A, Soori R, Akbarnejad A, Mishafiey S.A, F T. Effect of Resistance Training on Serum Levels of Adipolin and Insulin Resistance in Obese Women Biannual JAHSSP. 2015;3(1):11-30. (in persian)
19
20. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, et al. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. Journal of Biological Chemistry. 2011;286(40):34552-8.
20
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