%0 Journal Article %T The Effect of Eight Weeks of Voluntary and Forced Endurance Training and Royal Jelly Consumption on NF-κB Gene Expression and Antioxidant Agents in Trimethyltin-Treated Alzheimer's Rats %J Journal of Sport Biosciences %I University of Tehran %Z 2008-9325 %A Hasanloei, Awat %A Mohamadzadeh Salamat, Khalid %A Hosseini, Seyed Ali %A Akbarzadeh, Samad %D 2022 %\ 08/23/2022 %V 14 %N 2 %P 87-102 %! The Effect of Eight Weeks of Voluntary and Forced Endurance Training and Royal Jelly Consumption on NF-κB Gene Expression and Antioxidant Agents in Trimethyltin-Treated Alzheimer's Rats %K Alzheimer' %K s %K Antioxidant %K Endurance training %K Royal jelly %K NF-κB %R 10.22059/jsb.2022.337245.1505 %X Introduction: Alzheimer's disease causes hippocampal degeneration, memory loss, and dementia. However, the effect of voluntary and forced endurance training and royal jelly consumption on this disease is not clear.Aim:In this study, the effect of eight weeks of voluntary and forced endurance training and consumption of Royal Jelly (RJ) on NF-κB gene expression and antioxidant factors were investigated in trimethyltin (TMT)-treated Alzheimer’s rats.Methods: After induction of Alzheimer's disease with TMT, 60 male rats were randomly divided into eight groups, including: first and last week slaughtered Alzheimer's rats control, voluntary training (VT), forced swimming training (ST), sham, voluntary training + RJ consumption (VT + RJ), forced swimming training + RJ Consumption (ST + RJ),  and Royal Jelly Consumption (RJ) groups. Also, 12 rats were placed equally in the first and last week slaughtered healthy control groups. The VT and ST groups were placed in a spinning wheel and a special swimming pool for rodents respectively, for eight weeks, and three 60-minute sessions per week using the overload principle. The RJ groups peritoneally received 100 mg/kg/day of royal jelly for eight weeks. One-way ANOVA was used to statistically analyze the values ​​of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Beta 2 Microglobulin (B2m), and NF-κB.Results: TAC gene expression in the hippocampal tissue of ST and VT groups was significant compared with the healthy group (P = 0.02), but MDA gene expression (P=0.165), B2m (P=0.060), and NF-κB (P=0.069) were not significant.Conclusion: In general, voluntary and forced endurance training and Royal Jelly consumption improve the antioxidant gene expression in the hippocampal tissue of TMT-treated Alzheimer's rats. %U https://jsb.ut.ac.ir/article_88032_709efd13d086b4ef6f551c99ed7dd00e.pdf