%0 Journal Article %T Neuroprotective Effect of Voluntary Exercise on Dopamine and Tyrosine Hydroxylase in the Striatum of Parkinsonian Rats %J Journal of Sport Biosciences %I University of Tehran %Z 2008-9325 %A Aghasi, Mohammad %A Fallah Mohammadi, Ziya %A Hajizadeh Moghadam, Akbar %D 2013 %\ 09/23/2013 %V 5 %N 3 %P 41-52 %! Neuroprotective Effect of Voluntary Exercise on Dopamine and Tyrosine Hydroxylase in the Striatum of Parkinsonian Rats %K voluntary exercise %K 6-hydroxydopamine %K Tyrosine hydroxylase %K dopamine %K Parkinson %K rat %R 10.22059/jsb.2013.32185 %X Introduiction: This study aimed to investigate the protective effects of 12-week voluntary exercise using a running wheel on the striatum  dopaminergic neurons against 6-hydroxydopamine lesions in rats. Materials and method: Twenty five rats were divided into three groups including healthy, parkinson and training-parkinson. The training groups were housed in individual cages geared with running wheels. To induce parkinson, 250 microlitre of 6-hydroxydopamine (6-OHDA) dissolved in saline was administered intracerebrovenricular (ICV) by a stereotaxic apparatus. Tyrosine hydroxylase and dopamine levels in the striatum were measured by ELISA. The obtained data was analyzed using one-way analysis of variance (ANOVA) and least significant difference (LSD) post-hoc test. Results: The mean running distance of subjects was 5384 meter per day.In this study, dopamine levels between the exercise and parkinson control groups had significant differences. In other words, a decrease in the dopamine level was prevented in the training group (P=0.001). Dopamine levels in the exercise group remained almost the same level as the healthy group (P=0.129). However, the tyrosine hydroxylase level did not change in the training and control groups. Conclusion:Pre-treatment with the voluntary exercise causes an increase in the strength and life-span of dopaminergic neurons striatum against oxidative damage caused by 6-OHDA toxicity, and has a protective role against parkinson’s disease. %U https://jsb.ut.ac.ir/article_32185_2a6dd95b38b5dbc0dbd36f0ba040eec4.pdf