Identification of New Variants in Genes Related To Muscle Strength in an Elite Weightlifter Using Whole Exome Sequencing: A Case Report
Bahman
Ebrahimi
University of Mohaghegh Ardabili, Ardabil, Iran
author
Marefat
Siahkohyan
University Mohaghegh Ardabili, Unirversi
author
Ali
khazani
University Mohaghegh Ardabili, Unirversi
author
sajjad
anoshirvani
University Mohaghegh Ardabili, Unirversi
author
Lotfali
Bolboli
University Mohaghegh Ardabili, Unirversi
author
Maryam
Asadi
Department of Molecular Genetics, Science and Research Branch, Islamic Azad University, Fars, Iran.
author
text
article
2021
per
Genetic factors play an important role in athletic performance and its related phenotypes such as strength, power and aerobic capacity. Whole Exome Sequencing (WES) has great potential to explore all possible deoxiribnucleotide (DNA) variants associated with physical performance. However, this new technique has not been used in sports genetics research. Therefore the aim of this case study was to report new variants in genes involved in skeletal muscles strength in an elite weightlifter using WES. After obtaining an informed contest participated in this study from a 32-year-old man, who is a member of the Iranian national weightlifting team, 5 cc of blood was taken and then DNA was extracted. DNA samples were analyzed using the WES method. WES analysis of this elite weightlifter revealed missense mutations (230845794A>G and 230845977G>A) in AGT and (148206440G>A and 148206473G>C) in ADRB2 genes. Results of WES analysis revealed missense mutations in Power/Strength related genes in this elite athlete. However more studies with larger sample sizes are needed to reveal the relationship between these variants and performance of strength athletes.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
399
405
https://jsb.ut.ac.ir/article_81335_2a59b154c777291001cb5c4b5592315d.pdf
dx.doi.org/10.22059/jsb.2021.319109.1456
Impact of Cycling Versus Sitting in Hot water and land on serum CXCL1 and IL-6 and insulin resistance in males with Metabolic Syndrome
Mohammad Taher
Jahangiri
Master of Science of Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
author
Roghiyeh
Fakhrpour
Assistant Professor of Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.
author
Karim
Azali Alamdari
Associate Professor of Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran
author
text
article
2021
per
Aim: exercise and hot water immersion is likely to more increase serum IL-6 and CXCL1 as well as insulin resistance in patients with metabolic syndrome. However, no straight investigation has been done in this area. Therefore, the aim of study was to investigate effect of an acute cycling session while immersed in hot water versus land on serum IL-6 and CXCL1 level and also insulin resistance in male patients with metabolic syndrome.Methodology: 15 males with metabolic syndrome (age: 58.4±4.17, BMI: 31.27±3.27) experienced four test sessions (with 48 hour intervals) including on cycling or inactive sitting in hot water (42 0°C) head out immersion or land conditions with a cross over design. Each of cycling sessions were included on 30 min of interval activity at 50% of MHR. Blood samples were taken before and 15 min post intervention. The variables were quantified using Elisa and Enzymatic methods and the data were analyzed by ANOVA for repeated measurements (time series method) at 0.05 statistical significance level. Results: Cycling increased serum CXCL1 only in the hot water, while IL-6 elevation was only noted during land exercise (P<0.05). However, insulin resistance was lowered in both hot water (p=0.002) and land exercise (p=0.001) sessions with no difference for this decline, between the two sessions(p=0.217). Conclusion: Cycling within the hot water compared to land, do not provide a remarkable advantage regarding the amount of induced changes in serum IL-6 and CXCL1 and even insulin resistance. However, more investigations remain to be done because of the lack of evidence and study limitations.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
407
425
https://jsb.ut.ac.ir/article_86248_a175cf87b6ee7112530e325cd480e67f.pdf
dx.doi.org/10.22059/jsb.2021.322625.1465
Effect of eight weeks of continuous and high intensity interval training on UCP1 in visceral and subcutaneous white adipose tissue of obese rats
Maryam
Nourshahi
Associated professor, Faculty of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran
author
Fatemeh
Mir Khalafzadeh
MSc in exercise physiology , Faculty of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran
author
Fariba
Khodagholi
Associated professor, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
author
Nazanin
Abuzari
PHD student, Department of Biological Sciences in Sport and Health, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran
author
text
article
2021
per
Prevalence of obesity and its related disease is considered as a major health complication worldwide. Changing the phenotype of white adipose tissue to brown following exercise is currently being studied as one of the strategies to prevent obesity. The aim of this study was to investigate the effect of eight weeks of continuous and high intensity interval training (HIIT) on UCP1 of visceral and subcutaneous white adipose tissue in obese rats. Eighteen obese rats after eight weeks of high fat diet randomly divided into control, continuous training (CT) and HIIT groups. HIIT protocol included high intensity intervals (80-110 % vVO2max) and low intensity intervals (50 % vVO2max) and CT protocol included running with )65-75 % vVO2max( intensity. 48 hours after the last training session, rats were sacrificed, visceral and subcutaneous white adipose tissue were removed and UCP1 level was assessed through western blotting method. The results showed that eight weeks of CT and HIIT increase UCP1 in visceral and subcutaneous WAT (p<0.05), and this increase were higher in HIIT group regardless of visceral or subcutaneous adipose tissue (P<0.005). It seems that HIIT induce higher increase in UCP1 protein in visceral and subcutaneous white adipose tissue, so obese individuals can use this type of training to benefit obesity prevention affects and improvement of adipose tissue function.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
427
438
https://jsb.ut.ac.ir/article_78450_393f97f31605720b88142583c32b465e.pdf
dx.doi.org/10.22059/jsb.2020.301401.1394
The Effect of Consuming Artichoke Extract with Aerobic Training on Blood Glucose and Insulin Resistance and Its Relationship with the Cognitive Status in Elderly with Mild Cognitive Impairment
Mehran
Ghahramani
Assistant Professor, Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran
author
Yahya
Zare
Ph.D. Student, Department of Physical Education, Jahrom Branch, Islamic Azad University, Jahrom, Iran
author
Mohammad-Ali
Kohanpour
Assistant Professor , Department of Exercise Physiology, Lamerd Branch, Islamic Azad University, Lamerd, Iran
author
text
article
2021
per
Introduction: The aim of this study was to investigate the effect of 12 weeks of aerobic training and consumption of artichoke extract on blood glucose and insulin resistance and its relationship with the cognitive status in elderly with mild cognitive impairment (MCI). Methods: 40 elderly people who obtained a score between 21 and 25 from the MMSE questionnaire were randomly selected, and randomly divided into 4 groups: aerobic training, artichoke, aerobic training + artichoke, and placebo (each group 10 People) were placed. The interventions were performed for 12 weeks. The aerobic training consisted of eight minutes of running with intensity of 75 to 85% of the maximum stored heart rate in the first session. After two sessions added one minute to the running time, so that after 12 weeks, the running time reached 26 minutes. Artichoke extract was taken in capsules at a dose of 300 mg / kg body weight per day. Results: Blood glucose and insulin resistance decreased significantly in two groups of training and training + artichokes (P <0.05). Cognitive status increased significantly in the three intervention groups compared with the placebo group, which was higher in the training + artichoke group (P <0.05). As cognitive status increased, blood glucose and insulin resistance decreased (P <0.05). Conclusion: Consumption of artichoke extract along with aerobic training for 12 weeks can possibly slow the progressive course of mild cognitive impairment and may stop and prevent the onset of diabetes due to this disorder.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
439
450
https://jsb.ut.ac.ir/article_85265_07f013301af3914da5ce2de20e92df3a.pdf
dx.doi.org/10.22059/jsb.2021.326087.1477
The effect of a six-month combined care program with garlic supplementation on coagulation factors in middle-aged men with deep vein thrombosis
Hamed
Saed
1. PhD student ، Department of Exercise physiology ، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran
author
Sedigheh
Hosseinpour Delavar
Assistant Professor، Department of Exercise Physiology، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran (Corresponding Author)
author
Hassan
Safikhani
Assistant Professor، Department of Corrective Exercises ، Kermanshah Branch ، Islamic Azad University ، Kermanshah ، Iran
author
Mohammadreza
Sobhiyeh
Associate Professor , Department of Vascular & Endovascular Surgery, Clinical Research Development Center, Imam Reza Hospital، Kermanshah University of Medical Sciences ، Kermanshah , Iran
author
text
article
2021
per
The purpose of this study was to compare the effect of six-months of combined care program with garlic supplementation on coagulation factors (INR, PPT, PT) in middle-aged men with DVT. The present study was a quasi-experimental with a clinical trial design (code: IRCT20210718051924N1). Subjects were 40 men (age: 51.50 ±4.01 years, fat percentage: 28.63 ±3.24) with a history of at-least 3 years of DVT who were taking warfarin randomly divided into four groups: Combined-exercise, Combined-exercise +garlic, Garlic and Control. Combined-exercise for 24 weeks, 3 sessions per-week, first resistance training (50 to 60% 1RM) and then aerobic training (55 to 60% of the reserve-heart-rate). 1200mg daily garlic supplement was used in the form of capsules at ten o'clock in the morning. PT, PTT and INR factors were measured before and after 24 weeks. Two-way analysis of variance, paired t-test and Tukey post-hoc test were used (P<0.05). The results showed that both combined-exercise +garlic and consumption of garlic increased the PT (garlic 3.3%, p=0.004; exercise +supplement 13.3%, P=0.001) and INR (garlic 2%, p=0.013; exercise +supplement 46%, p=0.001) had a significant effect, also combined-exercise +garlic on the PTT 1.5% (p=0.014) had a significantly effect. But this wasn’t of effects in the combined-exercises (PT: p=0.355, INR: p=0.259, PTT: p=0.448) and the group Garlic was-not significant in PTT (p=0.504). It is recommended to use combined exercises with garlic consumption because of its effect on PT and INR and the important role of these factors in rebalancing homeostasis.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
451
471
https://jsb.ut.ac.ir/article_85755_9edebf96fedd0466b14d08c0a214dcc6.pdf
dx.doi.org/10.22059/jsb.2022.325432.1475
The effect of 8 weeks of high-intensity interval training on vascular calcification index in mice with type 2 diabetes
Elham
Khani Sanij
Student, Faculty of Sport Sciences and Health. Shahid Beheshti University, Tehran, Iran
author
Khosro
Ebrahim
Professor, Faculty of Sport Sciences and Health. Shahid Beheshti University, Tehran, Iran
author
Ebrahim
Rezvani
Professor, Department of Physiology, School of Medicine Shahid Sadoughi University of Medical Sciences. Yazd. Iran
author
Hossein
Azizian
Associated Professor, Department of Physiology, School of Medicine Shahid Sadoughi University of Medical Sciences. Yazd. Iran
author
text
article
2021
per
Diabetes mellitus (DM) is a chronic metabolic disease characterized by vascular classification and impaired carbohydrates, lipids, and lack of insulin secretion or decreased sensitivity to insulin metabolic effects. on the other hand, it seems the effect of exercise on vascular classification is an important issue. In the present study, we evaluated whether 8 weeks of high-intensity interval training (HIIT) decrease vascular calcification and improvement lipid profile in rats. Main Methods: 40 Male Wistar rats were randomly divided into diabetic (T2D), exercise-diabetic (EX-T2D), exercise (EX-CON), and control (CON) groups. After 5 weeks, diabetes was induced in all the T2D and the EX-T2D group. The EX-T2D group trained for 8 weeks. Real-time PCR and colorimetric were performed to investigate the expression of RUNX2 and lipid profile Key Findings: Rat in the T2D group had a significant increase in glucose, triglyceride, cholesterol (p≤0.001), and LDL(p≤0.05) as well as deceased in insulin and HDL (p≤0.05). compared to the control group. In exercise, groups of rats had a significant decrease in RUNX2 expression compared to the control group (p≤0.05). in addition, Triglyceride and cholesterol levels were lower in the EX-T2D group compared to the diabetes group (P≤0.05). Significance: Our data demonstrate that HIIT decreased vascular calcification and improved lipid profile in a mouse model of diabetes. However, further research is required to examine potential clinical relevance.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
473
488
https://jsb.ut.ac.ir/article_85373_c3ec7c631a257a458ef471afcd697433.pdf
dx.doi.org/10.22059/jsb.2022.324137.1469
The effect of nutrition education intervention on total calorie intake, macronutrient content, iron and vitamin D status of competitive adolescent soccer players
Abolfazl
Fijan
Phd student in exercise physiology, Department of Exercise Physiology, faculty of Education and Psychology, University of Shiraz, Iran
author
Farhad
Daryanoosh
Associate Professor of exercise physiology, Department of Exercise Physiology, faculty of Education and Psychology, University of Shiraz, Iran
author
Mohammad
Hemmatinafar
Assistant Professor of exercise physiology, Department of Exercise Physiology, faculty of Education and Psychology, University of Shiraz, Iran
author
Mohsen
Salesi
Associate Professor of exercise physiology, Department of Exercise Physiology, faculty of Education and Psychology, University of Shiraz, Iran
author
maryam
Koushkie Jahromi
full Professor of exercise physiology, Department of Exercise Physiology, faculty of Education and Psychology, University of Shiraz, Iran
author
text
article
2021
per
Objective: In addition to daily calorie intake, vitamin D and iron as micronutrients are the most important in the diet of athletes, especially in adolescence. Therefore, the aim of the present study was to investigate the effect of nutrition education intervention on total caloric intake, resting levels and iron and vitamin D intake in competitive adolescent soccer players. Methods: The subjects of this study consisted of 63 competitive adolescent soccer players in the country's premier league. In order to achieve the total caloric intake and the amount of micronutrients, the subjects were recalled for three days, then blood samples were taken to achieve resting amounts of vitamin D and iron. Nutrition education intervention group (n = 41) and control group (n = 22) The experimental group was trained for 4 weeks (8 sessions of 30 minutes of applied nutrition educating followed by 10 weeks of face-to-face counseling) by attending the website and online. To examine changes within and between groups of analysis Mixed variance and dependent and independent t-tests were used. Results: The results of intragroup mixed analysis of variance test on total calories, resting levels of vitamin D and vitamin D in the diet were significant (P = 0.001). Conclusion: Nutritional education intervention significantly increases total caloric intake, carbohydrate and protein intake, resting levels of vitamin D and intake of vitamin D in the diet of competitive adolescent soccer players, but on resting values and Dietary iron intake has no effect.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
489
509
https://jsb.ut.ac.ir/article_85759_87ed709c53a24ba34ceb5dce1da65eb9.pdf
dx.doi.org/10.22059/jsb.2022.333258.1494
The autonomic nervous system behavior following two weeks of moderate intensity interval training (MIIT) based body weight with surgical and N95 masks during the SARS-CoV-2 pandemic
Masoumeh
Fallah
Ph.D degree Student, Department of Sports Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
author
Valiollah
Dabidi Roshan
Department of Sports Physiology, Faculty of Physical EducProfessor, Department of Sports Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran. and Athletic Performance and Health Research Center, Department of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, Iranation and Sport Sciences, University, of Mazandaran, Babolsar, Iran.
author
Khadijeh
Nasiri
Assistant Professor, Department of Sports Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran
author
text
article
2021
per
During the COVID-19 pandemic, people are concerned about wearing a mask during physical activity and its effect on the cardiac autonomic system (ANS). The purpose of the study was the effect of 2-weeks of moderate-intensity interval training (MIIT) based body weight combined with wearing face masks (surgery against N95) on the ANS response of healthy men following the submaximal treadmill running protocol (STRP) and 5 minutes of recovery during the SARS-CoV-2 pandemic. This study,18 healthy men were randomly divided into 3 groups of 6 (surgical mask,N95 mask and Nomask) and MIIT exercises with and without surgical masks or N95 3-times a week, each session with 3-repetitions with intensity (60-70% Maximum-heart rate). Parasympathetic (RMSSD, HFn.u) and sympathetic parameters (LFn.u, LF/HF) and Change distance R-R were evaluated with electrocardiogram and Kubius software before and to 5 minutes of recovery. One-way ANOVA and Bonferroni post hoc test were used. The results showed, STRP protocol Implementation before 2-weeks of MIIT did not make a significant difference in LF, LF/HF, RMSSD, HF and mean RR values between the experimental groups (surgical mask against N95 mask) and also compared with the control group (without mask(. In addition, although the intergroup changes in sympathetic and parasympathetic indices and mean RR after 2-weeks of MIIT show relative improvement, they have not yet been statistically significant. Wearing facemasks during exercise training is safe for healthy men and 2 weeks of adaptation to interval training with face mask improves ANS performance.
Journal of Sport Biosciences
University of Tehran
2008-9325
13
v.
4
no.
2021
511
528
https://jsb.ut.ac.ir/article_86106_d79167e0a47ff8fa1c9d344a0932eacc.pdf
dx.doi.org/10.22059/jsb.2022.334247.1496